Erythrocyte antioxidant enzymes and their correlation with malondialdehyde in malaria

Benedicta D'Souza; Vivian D'Souza; H. Swagata; K. Vijayalaxmi; A. S. Namratha

Erythrocyte antioxidant enzymes and their correlation with malondialdehyde in malaria

Benedicta D'Souza, Vivian D'Souza, H. Swagata, K. Vijayalaxmi, A. S. Namratha

Research output: Contribution to journal › Article › peer-review

Abstract

Invasion of human erythrocytes by malaria parasites causes alterations in antioxidant potential of the red cells. The present study was undertaken to investigate the erythrocyte antioxidant enzymes like superoxide dismutase(SOD), catalase(CAT) in malaria patients. Oxidative stress was estimated by measuring malondialdehyde(MDA) which is a marker for lipid peroxidation. 30 malaria patients were enrolled in this study. They were divided into 2 groups of 15 each with Plasmodium vivax malaria and Plasmodium falciparum malaria. Results were compared with 20 healthy control subjects. Significant decrease(p<0.001) in SOD and CAT and increase in MDA (p<0.001) indicates that there is reduction in antioxidant enzymes and increased vulnerability to free radical damage in erythrocytes. This study therefore emphasizes the need for early treatment of malaria patients to reduce the red cell damage.

Original language	English
Pages (from-to)	25-27
Number of pages	3
Journal	Biomedical Research
Volume	20
Issue number	1
Publication status	Published - 15-05-2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Invasion of human erythrocytes by malaria parasites causes alterations in antioxidant potential of the red cells. The present study was undertaken to investigate the erythrocyte antioxidant enzymes like superoxide dismutase(SOD), catalase(CAT) in malaria patients. Oxidative stress was estimated by measuring malondialdehyde(MDA) which is a marker for lipid peroxidation. 30 malaria patients were enrolled in this study. They were divided into 2 groups of 15 each with Plasmodium vivax malaria and Plasmodium falciparum malaria. Results were compared with 20 healthy control subjects. Significant decrease(p<0.001) in SOD and CAT and increase in MDA (p<0.001) indicates that there is reduction in antioxidant enzymes and increased vulnerability to free radical damage in erythrocytes. This study therefore emphasizes the need for early treatment of malaria patients to reduce the red cell damage.",

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AU - D'Souza, Benedicta

AU - D'Souza, Vivian

AU - Swagata, H.

AU - Vijayalaxmi, K.

AU - Namratha, A. S.

PY - 2009/5/15

Y1 - 2009/5/15

N2 - Invasion of human erythrocytes by malaria parasites causes alterations in antioxidant potential of the red cells. The present study was undertaken to investigate the erythrocyte antioxidant enzymes like superoxide dismutase(SOD), catalase(CAT) in malaria patients. Oxidative stress was estimated by measuring malondialdehyde(MDA) which is a marker for lipid peroxidation. 30 malaria patients were enrolled in this study. They were divided into 2 groups of 15 each with Plasmodium vivax malaria and Plasmodium falciparum malaria. Results were compared with 20 healthy control subjects. Significant decrease(p<0.001) in SOD and CAT and increase in MDA (p<0.001) indicates that there is reduction in antioxidant enzymes and increased vulnerability to free radical damage in erythrocytes. This study therefore emphasizes the need for early treatment of malaria patients to reduce the red cell damage.

AB - Invasion of human erythrocytes by malaria parasites causes alterations in antioxidant potential of the red cells. The present study was undertaken to investigate the erythrocyte antioxidant enzymes like superoxide dismutase(SOD), catalase(CAT) in malaria patients. Oxidative stress was estimated by measuring malondialdehyde(MDA) which is a marker for lipid peroxidation. 30 malaria patients were enrolled in this study. They were divided into 2 groups of 15 each with Plasmodium vivax malaria and Plasmodium falciparum malaria. Results were compared with 20 healthy control subjects. Significant decrease(p<0.001) in SOD and CAT and increase in MDA (p<0.001) indicates that there is reduction in antioxidant enzymes and increased vulnerability to free radical damage in erythrocytes. This study therefore emphasizes the need for early treatment of malaria patients to reduce the red cell damage.

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Erythrocyte antioxidant enzymes and their correlation with malondialdehyde in malaria

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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