TY - JOUR
T1 - Erythrocyte miRNA regulators and malarial pathophysiology
AU - Prabhu, Sowmya R.
AU - Ware, Akshay P.
AU - Saadi, Abdul Vahab
N1 - Funding Information:
We thank Prof K. Satyamoorthy, Director, Manipal School of Life Sciences and Manipal Academy of Higher Education (MAHE), for the infrastructure and support. Dr. TMA Pai Ph.D. scholarship awarded to Sowmya R. Prabhu and Akshay P. Ware is gratefully acknowledged.
Publisher Copyright:
© 2021
PY - 2021/9
Y1 - 2021/9
N2 - Pathophysiology of Plasmodium falciparum and Plasmodium vivax in malaria vis a vis host and the parasite genome interactions has been deciphered recently to present the biology of cerebral malaria, severe anaemia and placental malaria. Small non-coding RNAs have exhibited their potential to be considered as indicators and regulators of diseases. The malarial pathologies and their associated mechanisms mediated by miRNAs and their role in haematopoiesis and red cell-related disorders are elucidated. Evidence of miRNA carrying exosome-like vesicles released during infection, delivering signals to endothelial cells enhancing gene expression, resulting in parasite sequestration and complications leading to pathologies of cerebral malaria are important breakthroughs. Pregnancy malaria showed Plasmodium surface antigen promoted erythrocyte sequestration in the placental intervillous space, provoking disease development and assorted complications. Syncytiotrophoblast-derived microparticles during pregnancy and fetus development may predict pathophysiological progression on account of their altered miRNA cargoes in malaria.
AB - Pathophysiology of Plasmodium falciparum and Plasmodium vivax in malaria vis a vis host and the parasite genome interactions has been deciphered recently to present the biology of cerebral malaria, severe anaemia and placental malaria. Small non-coding RNAs have exhibited their potential to be considered as indicators and regulators of diseases. The malarial pathologies and their associated mechanisms mediated by miRNAs and their role in haematopoiesis and red cell-related disorders are elucidated. Evidence of miRNA carrying exosome-like vesicles released during infection, delivering signals to endothelial cells enhancing gene expression, resulting in parasite sequestration and complications leading to pathologies of cerebral malaria are important breakthroughs. Pregnancy malaria showed Plasmodium surface antigen promoted erythrocyte sequestration in the placental intervillous space, provoking disease development and assorted complications. Syncytiotrophoblast-derived microparticles during pregnancy and fetus development may predict pathophysiological progression on account of their altered miRNA cargoes in malaria.
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U2 - 10.1016/j.meegid.2021.105000
DO - 10.1016/j.meegid.2021.105000
M3 - Review article
AN - SCOPUS:85111035365
SN - 1567-1348
VL - 93
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
M1 - 105000
ER -
