High burden of antimicrobial resistance among critical priority pathogens is a major challenge facing humankind. In particular, ESKAPE pathogens - which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. - have received wide attention due to their immense clinical importance. Several studies indicate that the biofilm mediated infections associated with these bacteria serve to increase their resistance towards antibiotics, necessitating the urgent need to develop more efficacious and safer drugs. Naturally occurring chalcones, which are precursors of flavonoids, have received wider attention for their potent antibacterial and antibiofilm activity. The ease of synthesis of diverse array of chalcones make them ideal candidates in drug screening programs while chalcone-based derivates and hybrids have been shown to have improved bioactivity, potency and functionality. Future prospects include designing novel chalcones using methods such as bioisosterism as well as developing large-scale screening methods to screen natural and synthetic chalcone libraries for potent antibiofilm activity against ESKAPE pathogens.
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