TY - JOUR
T1 - Escaping ESKAPE
T2 - A chalcone perspective
AU - Uchil, Ashwini
AU - Murali, Thokur Sreepathy
AU - Nayak, Roopa
N1 - Funding Information:
The authors thank Dr. K Satyamoorthy, Director, Manipal School of Life Sciences, for his constant support and guidance. We also thank TIFAC – CORE in Pharmacogenomics, Manipal School of Life Sciences and Manipal Academy of Higher Education for providing the infrastructure and facilities. RN thanks Vision Group on Science and Technology , Karnataka for funding ( VGST/RGS-F/GRD-887/2019-20/2020-21/198 ) and MAHE for providing Seed Grant.
Funding Information:
The authors thank Dr. K Satyamoorthy, Director, Manipal School of Life Sciences, for his constant support and guidance. We also thank TIFAC ? CORE in Pharmacogenomics, Manipal School of Life Sciences and Manipal Academy of Higher Education for providing the infrastructure and facilities. RN thanks Vision Group on Science and Technology, Karnataka for funding (VGST/RGS-F/GRD-887/2019-20/2020-21/198) and MAHE for providing Seed Grant. Vision Group on Science and Technology, Karnataka to RN (VGST/RGS-F/GRD-887/2019-20/2020-21/198) and Seed Grant from MAHE to RN. This article does not contain any studies with human participants or animals performed by any of the authors. Roopa Nayak and Murali contributed to the idea of the article. Literature search and compilation were performed by Ashwini Uchil. First draft was written by Ashwini Uchil and critically revised by Murali, and Roopa. All the authors read and approved the final manuscript.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/1
Y1 - 2021/1
N2 - High burden of antimicrobial resistance among critical priority pathogens is a major challenge facing humankind. In particular, ESKAPE pathogens - which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. - have received wide attention due to their immense clinical importance. Several studies indicate that the biofilm mediated infections associated with these bacteria serve to increase their resistance towards antibiotics, necessitating the urgent need to develop more efficacious and safer drugs. Naturally occurring chalcones, which are precursors of flavonoids, have received wider attention for their potent antibacterial and antibiofilm activity. The ease of synthesis of diverse array of chalcones make them ideal candidates in drug screening programs while chalcone-based derivates and hybrids have been shown to have improved bioactivity, potency and functionality. Future prospects include designing novel chalcones using methods such as bioisosterism as well as developing large-scale screening methods to screen natural and synthetic chalcone libraries for potent antibiofilm activity against ESKAPE pathogens.
AB - High burden of antimicrobial resistance among critical priority pathogens is a major challenge facing humankind. In particular, ESKAPE pathogens - which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. - have received wide attention due to their immense clinical importance. Several studies indicate that the biofilm mediated infections associated with these bacteria serve to increase their resistance towards antibiotics, necessitating the urgent need to develop more efficacious and safer drugs. Naturally occurring chalcones, which are precursors of flavonoids, have received wider attention for their potent antibacterial and antibiofilm activity. The ease of synthesis of diverse array of chalcones make them ideal candidates in drug screening programs while chalcone-based derivates and hybrids have been shown to have improved bioactivity, potency and functionality. Future prospects include designing novel chalcones using methods such as bioisosterism as well as developing large-scale screening methods to screen natural and synthetic chalcone libraries for potent antibiofilm activity against ESKAPE pathogens.
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U2 - 10.1016/j.rechem.2021.100229
DO - 10.1016/j.rechem.2021.100229
M3 - Article
AN - SCOPUS:85118879783
SN - 2211-7156
VL - 3
JO - Results in Chemistry
JF - Results in Chemistry
M1 - 100229
ER -