Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells

Shagufta Parveen

doi:10.1016/j.scr.2017.12.008

Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells

Shagufta Parveen

Manipal Institute of Regenerative Medicine, Bangalore

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Human term placenta is a bulky organ which harbours abundant mesenchymal stromal cells. This study reports isolation and characterization of placental mesenchymal stromal cells (PMSCs) followed by reprogramming of PMSCs to induced pluripotent stem cells (iPSCs). The placental human iPSC (PhiPSC) line is pluripotent with high telomerase activity, genetically identical to parental PMSCs, transgene free, karyotypically normal and differentiates into ectoderm, mesoderm and endoderm both in vitro and in vivo. Thus PMSCs serve as a unique cell type for human perinatal iPSC derivation from extra embryonic tissue.

Original language	English
Pages (from-to)	15-20
Number of pages	6
Journal	Stem Cell Research
Volume	27
DOIs	https://doi.org/10.1016/j.scr.2017.12.008
Publication status	Published - 01-03-2018

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

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10.1016/j.scr.2017.12.008

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title = "Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells",

abstract = "Human term placenta is a bulky organ which harbours abundant mesenchymal stromal cells. This study reports isolation and characterization of placental mesenchymal stromal cells (PMSCs) followed by reprogramming of PMSCs to induced pluripotent stem cells (iPSCs). The placental human iPSC (PhiPSC) line is pluripotent with high telomerase activity, genetically identical to parental PMSCs, transgene free, karyotypically normal and differentiates into ectoderm, mesoderm and endoderm both in vitro and in vivo. Thus PMSCs serve as a unique cell type for human perinatal iPSC derivation from extra embryonic tissue.",

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AB - Human term placenta is a bulky organ which harbours abundant mesenchymal stromal cells. This study reports isolation and characterization of placental mesenchymal stromal cells (PMSCs) followed by reprogramming of PMSCs to induced pluripotent stem cells (iPSCs). The placental human iPSC (PhiPSC) line is pluripotent with high telomerase activity, genetically identical to parental PMSCs, transgene free, karyotypically normal and differentiates into ectoderm, mesoderm and endoderm both in vitro and in vivo. Thus PMSCs serve as a unique cell type for human perinatal iPSC derivation from extra embryonic tissue.

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JO - Stem Cell Research

JF - Stem Cell Research

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Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells

Abstract

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