Estimation of the solubility parameter of trimethoprim by current methods

C.V.S. Subrahmanyam; K.R. Prakash; P.G. Rao

doi:10.1016/0031-6865(96)00015-5

Estimation of the solubility parameter of trimethoprim by current methods

C.V.S. Subrahmanyam, K.R. Prakash, P.G. Rao

Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Group contribution, the extended Hildebrand solubility (EHS) and the extended Hansen solubility approaches are utilised to estimate the solubility parameter value of trimethoprim. The solubility data in the binary solvent series showed peak solubility at the solubility parameter of solvent, 11.7 H. The regression expression on the lines of the EHS approach yielded 12.06 H. The data on the solubility of trimethoprim in individual solvents was processed as per the extended Hansen approach. The partial solubility parameters were obtained and are used to estimate the solubility parameter, 12.93 H. Extending the Flory-Huggins size correction to this approach gave a value of 10.95 H and improved the correlation coefficient by 3 percent. Partitioning of hydrogen bonding (four parameter approach) didn't improve the value.

Original language	Undefined/Unknown
Pages (from-to)	175-183
Number of pages	9
Journal	Pharmaceutica Acta Helvetiae
Volume	71
Issue number	3
DOIs	https://doi.org/10.1016/0031-6865(96)00015-5
Publication status	Published - 1996

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title = "Estimation of the solubility parameter of trimethoprim by current methods",

abstract = "Group contribution, the extended Hildebrand solubility (EHS) and the extended Hansen solubility approaches are utilised to estimate the solubility parameter value of trimethoprim. The solubility data in the binary solvent series showed peak solubility at the solubility parameter of solvent, 11.7 H. The regression expression on the lines of the EHS approach yielded 12.06 H. The data on the solubility of trimethoprim in individual solvents was processed as per the extended Hansen approach. The partial solubility parameters were obtained and are used to estimate the solubility parameter, 12.93 H. Extending the Flory-Huggins size correction to this approach gave a value of 10.95 H and improved the correlation coefficient by 3 percent. Partitioning of hydrogen bonding (four parameter approach) didn't improve the value.",

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T1 - Estimation of the solubility parameter of trimethoprim by current methods

AU - Subrahmanyam, C.V.S.

AU - Prakash, K.R.

AU - Rao, P.G.

N1 - cited By 20

PY - 1996

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N2 - Group contribution, the extended Hildebrand solubility (EHS) and the extended Hansen solubility approaches are utilised to estimate the solubility parameter value of trimethoprim. The solubility data in the binary solvent series showed peak solubility at the solubility parameter of solvent, 11.7 H. The regression expression on the lines of the EHS approach yielded 12.06 H. The data on the solubility of trimethoprim in individual solvents was processed as per the extended Hansen approach. The partial solubility parameters were obtained and are used to estimate the solubility parameter, 12.93 H. Extending the Flory-Huggins size correction to this approach gave a value of 10.95 H and improved the correlation coefficient by 3 percent. Partitioning of hydrogen bonding (four parameter approach) didn't improve the value.

AB - Group contribution, the extended Hildebrand solubility (EHS) and the extended Hansen solubility approaches are utilised to estimate the solubility parameter value of trimethoprim. The solubility data in the binary solvent series showed peak solubility at the solubility parameter of solvent, 11.7 H. The regression expression on the lines of the EHS approach yielded 12.06 H. The data on the solubility of trimethoprim in individual solvents was processed as per the extended Hansen approach. The partial solubility parameters were obtained and are used to estimate the solubility parameter, 12.93 H. Extending the Flory-Huggins size correction to this approach gave a value of 10.95 H and improved the correlation coefficient by 3 percent. Partitioning of hydrogen bonding (four parameter approach) didn't improve the value.

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DO - 10.1016/0031-6865(96)00015-5

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VL - 71

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JO - Pharmaceutica Acta Helvetiae

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