@article{828ea6ff062246119d4cd9e3a1367c70,
title = "Ethanol extract of Crataeva nurvala stem bark reverses cisplatin-induced nephrotoxicity",
abstract = "Generation of free radicals in the kidney cortex plays an important role in the pathogenesis of cisplatin-induced dysfunction of renal proximal tubule cells. Previous studies carried out showed that an alcohol extract of Crataeva nurvala stem bark possessed antioxidant activity in rats, hence the present work aimed at evaluating the possible effect of the alcohol extract of C. nurvala on cisplatin-induced dysfunction model of renal proximal tubule cells by oxidative stress. The alcohol extract was administered orally for ten days at two dose levels of 250 and 500 mg/kg body weight, five days after administration of a single i.p. dose of cisplatin (5 mg/kg). Renal dysfunction was evaluated histologically by light microscopy and biochemically by measuring the concentrations of blood urea nitrogen, serum creatinine, lipid peroxidation, glutathione and catalase activity in the kidney cortex. The results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under oxidative stress by decreasing the concentration of blood urea nitrogen, creatinine and lipid peroxidation. The increased glutathione and catalase activity are indicative of the antioxidant properties of C. nurvala stem bark extract.",
author = "A. Shirwaikar and M.M. Setty and P. Bommu and B. Krishnanand",
note = "Cited By :8 Export Date: 10 November 2017 CODEN: PHBIF Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal - 576 104, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; catalase, 9001-05-2; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; creatinine, 19230-81-0, 60-27-5; glutathione, 70-18-8 Manufacturers: Dabur, India References: Anand, R., Patnaik, G.K., Kulshreshtha, D.K., Mehrotra, B.N., Srimal, R.C., Dhawan, B.N., Antiurolithiatic activity of Crataeva nurvala ethanolic extract on rats (1993) Fitoterapia, 64, p. 345; Baskar, R., Malini, M., Varalakshmi, P., Effect of lupeol isolated from Crataeva nurvala stem bark against free radical-induced toxicity in experimental urolithiasis (1996) Fitoterapia, 67, pp. 121-125; Bramley, P.M., Pridham, J.B., The relative antioxidant activities of plant derived polyphenolic flavanoids (1995) Free Radical Res, 4, pp. 375-383; Ellman, G.L., Tissue sulphydryl groups (1959) Arch Biochem Biophys, 82, pp. 70-77; Fantone, J.C., Ward, P.A., Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions (1992) Am J Pathol, 107, pp. 397-418; Fox, R.B., Prevention of granulocyte-mediated oxidative injury in rats by a hydroxyl radical scavenger, dimethylthiocarbide (1984) J Clin Invest, 74, pp. 1456-1464; Fraga, C.G., Leibovita, B.E., Toppel, A.L., Lipid peroxidation measured as TBARS in tissue slices: Characterisation and comparison with homogenates and microsomes (1988) Free Radic Biol Med, 4, pp. 155-161; Goldstein, R.S., Mayor, G.H., The nephrotoxicity of cisplatin (1983) Life Sci, 32, pp. 685-690; Harborne, J.B., (1984) Phytochemical Methods, pp. 123-175. , London, Chapman and Hall; Henry, R.J., (1963) Clin Chem Principle and Techniques, p. 268. , New York, Harper & Row; Kim, Y.K., Jung, J.S., Lee, S.H., Kim, Y.W., Effects of anti-oxidants and calcium in cisplatin induced cell injury in rabbit renal cortical slices (1997) Toxicol Appl Pharmacol, 146, pp. 261-269; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with Folin-phenol reagent (1951) J Biol Chem, 193, pp. 265-275; McGinness, J.E., Proctor, P.H., Demopaulos, H.B., Hockanson, J.A., Kirkpatrick, D.S., Amelioration of cisplatin nephrotoxicity by orgotein (superoxide dismutase) (1978) Physiol Chem Phys, 10, pp. 267-272; Nandkarni, K.M., (2000) Indian Materia Medica, pp. 387-388. , Bombay, India, Popular Book Depot; Mayne, P.D., Diagnosis of renal function in Clinical Chemistry in Diagnosis and Treatment (1994) ELBS, 1, pp. 1-25; Sdzuka, Y., Shoji, T., Takino, Y., Effect of cisplatin on the activation of enzymes which protect against lipid peroxidation (1992) Biochem Pharmacol, 43, pp. 1872-1875; Shah, S.V., Effect of enzymatically generated reactive oxygen metabolites on the cyclic nucleotide content in isolated glomeruli (1984) J Clin Invest, 74, pp. 393-401; Shah, S.V., Barcos, W.H., Basci, A., Degradation of human glomerular basement membrane by stimulated neutrophils. Activation of a metallaproteinase by reactive oxygen metabolite (1987) J Clin Invest, 79, pp. 25-31; Sinha, K.A., Colorimetric assay of catalase (1972) Annal Biochem, 47, pp. 389-394; Sugihara, K., Nakano, S., Koda, M., Tanaka, K., Fukuishi, N., Gemba, M., Stimulatory effect of cisplatin on lipid peroxidation in renal tissues (1987) Jpn J Pharmacol, 43, pp. 247-252; Sunitha, S., Nagaraj, M., Varalakshmi, P., Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defense system in cadmium-induced hepatotoxicity in rats (2001) Fitoterapia, 72, pp. 516-523; Tietz, N.W., (1986) Fundamentals of Clinical Chemistry, p. 1278. , Philadelphia, WB Saundars and Company; Varani, J., Fligiel, S.E., Till, G.O., Kunkel, R.G., Ryan, U.S., Ward, P.A., Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical (1985) Lab Invest, 53, pp. 656-663; Weiss, S.J., LoBuglio, A.F., Phagocyte-generated oxygen metabolites and cell injury (1982) Lab Invest, 47, pp. 5-18; Zhang, J.G., Lindup, W.E., Cisplatin nephrotoxicity decreases in mitochondrial protein sulfhydryl concentration and calcium uptake by mitochondria from rat renal cortical slices (1994) Biochem Pharmacol, 47, pp. 1127-1135; Zhong, L.F., Zhang, G., Zhang, M., Ma, S.L., Xia, Y.X., Lipid peroxidation and kidney damage by procaine in rats (1990) Arch Toxicol, 64, pp. 599-600",
year = "2004",
doi = "10.1080/13880200490901249",
language = "English",
volume = "42",
pages = "559--564",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Informa Healthcare",
number = "7",
}