Evaluation of alpha 1-antitrypsin, protein carbonyl and carboxy-Hb in COPD patients

V. Vijay, Asha Kamath, Vivian D'souza, M. Nandini

Research output: Contribution to journalArticlepeer-review


Chronic obstructive pulmonary disease (COPD) is one among the common lung diseases, caused by cigarette smoking. The increased risk of developing emphysema among smokers is suggested to result from a decrease in alpha 1 antitrypsin (a1-AT). Evaluation of a1-AT activity, protein carbonyl and carboxy-Hb levels, which contribute to the disease process in COPD patients, is the main aim of the study. Study group included 30 male COPD patients aged 45-65 years with history of COPD > 5yrs and tobacco smoking > 20yrs. Control group included 25 normal healthy individuals of the same age group. A decrease in a1-AT (p < 0.000) and increase in protein carbonyl (p < 0.000) with no significant change in carboxy-Hb levels was observed. The findings of the study strongly suggest that oxidative stress plays a key role in the disease process of COPD. Evaluation of protein carbonyl along with a1-AT aids in assessing the severity of the disease.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalBiomedicine (India)
Issue number1
Publication statusPublished - 01-2009

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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