Evaluation of antioxidant and antiparkinsonian activities of Brassica oleracea in haloperidol-induced tardive dyskinesia

Background: Brassica oleracea is a leafy green vegetable commonly called as cabbage. It belongs to the family Brassicaceae. Studies reveal that it is rich in flavonoids and has high antioxidant property. Aims: The present study was aimed at evaluating antiparkinsonian activity of B. oleracea in haloperidol-induced tardive dyskinesia. Settings and Design: The present study was designed for 14 days administration of the plant extract then behavioral and biochemical parameters were estimated in the rats. Materials and Methods: B. oleracea was collected, dried in the shade, powdered, and subjected to the extraction by cold maceration using water and methanol mixture of H₂O/CH₃OH as a solvent. The extract was subjected to preliminary phytochemical screening. Haloperidol model was selected for screening antiparkinsonian activity, and it was administered at a dose of 1 mg/kg i.p., for 14 days. Behavioral and biochemical parameters were estimated in all the groups. Statistical Analysis Used: Statistical significance between more than two groups was tested using one-way ANOVA followed by the Bonferroni′s compare all columns test using the computer-based fitting program. Results: In groups treated with hydroalcoholic extract of B. oleracea (250 and 500 mg/kg p.o.,) decreased the elevated levels of lipid peroxidation in the haloperidol-treated animals and elevated the cellular defense mechanisms such as glutathione, further suggesting the role of free radicals in the pathophysiology of the haloperidol-induced extrapyramidal syndrome. Conclusion: This study reveals the use of B. oleracea in parkinsonian disease.