Formulations containing ciprofloxacin hydrochloride and norfloxacin for the treatment of ophthalmic and skin infections were made. The stability, bioavailability and therapeutic efficacy of the preparations were evaluated. These antibiotics were not systematically absorbed, when applied locally. Preparations were found more effective for the treatment of skin and eye infections. Betacyclodextrin improved the bioavailability of antibiotics.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry
- Molecular Medicine