Evaluation of hypoglycemic effects of 4-thiazolidinones

J.M. Joy, N. Jacob, G.N. Kutty

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9 Citations (Scopus)


Nicotinic acid, a well-known hypolipidemic drug, is known to produce elevation of blood glucose in humans. In an earlier study in our laboratory, a thiazolidinone derivative of nicotinic acid was shown to exert hypolipidemic effect. The present study was aimed to find out if this compound produced any elevation of blood glucose in normal and diabetic Wistar rats. A closely related thiazolidinone was also evaluated. The two compounds reduced blood glucose in both normal and diabetic rats, while nicotinic acid produced hyperglycemia. The thiazolidinone structure with its hypoglycemic potential may be opposing the glucose elevating effect of nicotinoyl moiety. It is concluded from the study that the thiazolidinone derivative of nicotinic acid is a hypoglycemic agent besides being hypolipidemic. Detailed investigation is warranted.
Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalIndian Drugs
Issue number1
Publication statusPublished - 2005


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