TY - JOUR
T1 - Evaluation of nitric oxide scavenging activity of certain spices in vitro
T2 - A preliminary study
AU - Baliga, Manjeshwar Shrinath
AU - Jagetia, Ganesh Chandra
AU - Rao, Shaival Kamalaksha
AU - Babu S, Kiran
PY - 2003/8/1
Y1 - 2003/8/1
N2 - The plant extracts of some commonly used spices were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as a NO donor in vitro. Most of the extracts tested demonstrated direct scavenging of NO and exhibited significant activity and the potency of scavenging activity was in the following order: Foeniculum vulgare (aqueous) +~ Citrus limettiodes +~ Murraya koenigii (seed, aqueous) +~ Murraya koenigii (leaf, aqueous) +~ Curcuma aromatica (aqueous) +~ Murraya koenigii (leaf, dichloromethane:methanol) +~ Mentha arvensis (chloroform) +~ Mentha arvensis (aqueous) +~ Curcuma longa +~ Gingko biloba +~ Foeniculum vulgare (dichloromethane:methanol) +~ Zingiber officinale (aqueous) +~ Curcuma aromatica (ethanolic) +~ Murraya koenigii (seed, dichloromethane:methanol). All the evaluated extracts exhibited a dose-dependent NO scavenging activity. The aqueous extract of Foeniculum vulgare showed a greatest NO scavenging effect of 79.75% at 62.5 μg/mL as compared to the positive control, Gingko biloba where 36.22% scavenging was observed at similar concentration. The present results suggest that these spices might be potent and novel therapeutic agents for scavenging of NO and the regulation of pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite.
AB - The plant extracts of some commonly used spices were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as a NO donor in vitro. Most of the extracts tested demonstrated direct scavenging of NO and exhibited significant activity and the potency of scavenging activity was in the following order: Foeniculum vulgare (aqueous) +~ Citrus limettiodes +~ Murraya koenigii (seed, aqueous) +~ Murraya koenigii (leaf, aqueous) +~ Curcuma aromatica (aqueous) +~ Murraya koenigii (leaf, dichloromethane:methanol) +~ Mentha arvensis (chloroform) +~ Mentha arvensis (aqueous) +~ Curcuma longa +~ Gingko biloba +~ Foeniculum vulgare (dichloromethane:methanol) +~ Zingiber officinale (aqueous) +~ Curcuma aromatica (ethanolic) +~ Murraya koenigii (seed, dichloromethane:methanol). All the evaluated extracts exhibited a dose-dependent NO scavenging activity. The aqueous extract of Foeniculum vulgare showed a greatest NO scavenging effect of 79.75% at 62.5 μg/mL as compared to the positive control, Gingko biloba where 36.22% scavenging was observed at similar concentration. The present results suggest that these spices might be potent and novel therapeutic agents for scavenging of NO and the regulation of pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite.
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U2 - 10.1002/food.200390061
DO - 10.1002/food.200390061
M3 - Article
C2 - 13678266
AN - SCOPUS:0242690916
SN - 1613-4125
VL - 47
SP - 261
EP - 264
JO - Die Nahrung
JF - Die Nahrung
IS - 4
ER -