Evaluation of the hypoglycemic, hypolipidemic and hepatic glycogen raising effects of Syzygium malaccense upon streptozotocin induced diabetic rats

Objective: To study the effect of Syzygium malaccense on serum glucose, lipid profile and liver glycogen content in both normal and hyperglycemic rats. Methods: The aqueous and alcoholic extracts were compared with glibenclamide for their influence on fasting blood sugar, lipid profile and liver glycogen in both normoglycemic and to streptozotocin induced (50mg/kg ip) hyperglycemic rats. Results: In normoglycemic rats the aqueous and alcoholic extracts produced hypoglycemia but did not affect the lipid profile and liver glycogen content even on chronic treatment. In the hyperglycemic rats on chronic treatment both the extracts caused reduction in FBS and significantly reversed the diabetes induced hyperlipidemia and liver glycogen depletion. The alcoholic extract was found to be more active than aqueous and equivalent to that of glibenclamide. Conclusion: The extracts of Syzygium malaccense with their beneficial effects on blood sugar and hyperlipidemia associated with diabetes could serve as good adjuvant to other oral hypoglycemic agents.