Evaluation of wound healing activity of leaf extract of Alstonia scholaris Linn. In rats

Y. L. Ramachandra, H. V. Sudeep, Padmalatha S. Rai, K. Ramadas

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Alstonia scholaris Linn. (Apocynaceae) is a medium sized tree known for its pharmacological activities like antimicrobial, antimalarial, anticholeric properties etc. The present study was aimed to assess the wound healing potential of crude methanol extract of A. scholaris (leaf) using three types of wound models in rats as incision wound, excision wound and dead space wound. The results were obtained with respect to the parameters such as wound contraction, epithelialization time, tensile strength, hydroxyproline content and granuloma weight. Enhanced wound contraction and decreased epithelialization time were observed in extract-treated animals in excision wound model. The tensile strength of the incision wound was significantly increased in comparison to control group. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in treated animals compared with control.

Original languageEnglish
Pages (from-to)390-393
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Issue numberSUPPL.1
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science


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