TY - JOUR
T1 - Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
AU - Shetgaonkar, Gayatri Gopal
AU - Marques, Shirleen Miriam
AU - DCruz, Cleona E.M.
AU - Vibhavari, R. J.A.
AU - Kumar, Lalit
AU - Shirodkar, Rupesh Kalidas
N1 - Funding Information:
Open access funding provided by Manipal Academy of Higher Education, Manipal Indian Council for Medical Research (ICMR), New Delhi (India), provided Senior Research Fellowship (SRF) to Gayatri Gopal Shetgaonkar in the proposed area of research. Department of Health Research (DHR), New Delhi (India), funded Dr. Lalit Kumar for doing the research in the proposed arena.
Publisher Copyright:
© 2021, The Author(s).
PY - 2022/5
Y1 - 2022/5
N2 - Exosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like in case of various diseases, based on the parent cells, the content of exosomes (protein, mRNA, miRNA, DNA, lipids and metabolites) varies and thus can be utilized as potential biomarker for diagnosis and prognosis of the brain diseases. Furthermore, utilizing the natural potential exosomes to cross the blood–brain barrier and by specifically decorating it with the ligand as per the desired brain sites therapeutics can be delivered to brain parenchyma. This review article conveys the importance of exosomes and their use in the treatment and diagnosis of brain/central nervous system diseases. Graphical abstract: [Figure not available: see fulltext.]
AB - Exosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like in case of various diseases, based on the parent cells, the content of exosomes (protein, mRNA, miRNA, DNA, lipids and metabolites) varies and thus can be utilized as potential biomarker for diagnosis and prognosis of the brain diseases. Furthermore, utilizing the natural potential exosomes to cross the blood–brain barrier and by specifically decorating it with the ligand as per the desired brain sites therapeutics can be delivered to brain parenchyma. This review article conveys the importance of exosomes and their use in the treatment and diagnosis of brain/central nervous system diseases. Graphical abstract: [Figure not available: see fulltext.]
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U2 - 10.1007/s13346-021-01026-0
DO - 10.1007/s13346-021-01026-0
M3 - Review article
AN - SCOPUS:85112651768
SN - 2190-393X
VL - 12
SP - 1047
EP - 1079
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
IS - 5
ER -