TY - JOUR
T1 - Exploring potential formulation strategies for chemoprevention of breast cancer
T2 - A localized delivery perspective
AU - Hegde, Aswathi R.
AU - Raychaudhuri, Ruchira
AU - Pandey, Abhijeet
AU - Kalthur, Guruprasad
AU - Mutalik, Srinivas
N1 - Funding Information:
The authors are thankful to the Council for Scientific and Industrial Research (CSIR; Government of India, New Delhi) for the Junior Research Fellowship to R Raychaudhuri and to Manipal Academy of Higher Education (Manipal) for the Postdoctoral Research Fellowship to A Pandey. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2021 Future Medicine Ltd.. All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - This review focuses on the various formulation approaches that have been explored to achieve localized delivery in breast cancer. The rationale behind the necessity of localized drug delivery has been extensively reviewed. The review also emphasizes the various possible routes for achieving localized drug delivery. Particularly, different types of nanoplatforms like lipid-based drug carriers, polymeric particles, hydrogels, drug conjugates and other formulation strategies like microneedles and drug-eluting implants, which have been used to increase tumor retention and subsequently halt tumor progression, have been deliberated here. In addition, the significant challenges that may be encountered in the delivery of anticancer drugs and the aspects that require careful evaluation for effective localized delivery of chemotherapeutic agents have been discussed.
AB - This review focuses on the various formulation approaches that have been explored to achieve localized delivery in breast cancer. The rationale behind the necessity of localized drug delivery has been extensively reviewed. The review also emphasizes the various possible routes for achieving localized drug delivery. Particularly, different types of nanoplatforms like lipid-based drug carriers, polymeric particles, hydrogels, drug conjugates and other formulation strategies like microneedles and drug-eluting implants, which have been used to increase tumor retention and subsequently halt tumor progression, have been deliberated here. In addition, the significant challenges that may be encountered in the delivery of anticancer drugs and the aspects that require careful evaluation for effective localized delivery of chemotherapeutic agents have been discussed.
UR - http://www.scopus.com/inward/record.url?scp=85106992348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106992348&partnerID=8YFLogxK
U2 - 10.2217/nnm-2021-0018
DO - 10.2217/nnm-2021-0018
M3 - Review article
C2 - 33949895
AN - SCOPUS:85106992348
SN - 1743-5889
VL - 16
SP - 1111
EP - 1132
JO - Nanomedicine
JF - Nanomedicine
IS - 13
ER -
