TY - JOUR
T1 - Exploring the multifactorial aspects of Gut Microbiome in Parkinson’s Disease
AU - Pavan, Sujith
AU - Prabhu, Arvind N.
AU - Prasad Gorthi, Sankar
AU - Das, Bhabatosh
AU - Mutreja, Ankur
AU - Shetty, Vignesh
AU - Ramamurthy, Thandavarayan
AU - Ballal, Mamatha
N1 - Funding Information:
Thankfully acknowledge the Manipal Academy of Higher Education.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/10
Y1 - 2022/10
N2 - Advanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak’s hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson’s Disease (PD), studies have explored and revealed the involvement of altered gut microbiota in PD. This review recapitulates the gut microbiome associated with PD severity, duration, motor and non-motor symptoms, and antiparkinsonian treatment from recent literature. Gut microbial signatures in PD are potential predictors of the disease and are speculated to be used in early diagnosis and treatment. In brief, the review also emphasises on implications of the prebiotic, probiotic, faecal microbiota transplantation, and dietary interventions as alternative treatments in modulating the disease symptoms in PD.
AB - Advanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak’s hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson’s Disease (PD), studies have explored and revealed the involvement of altered gut microbiota in PD. This review recapitulates the gut microbiome associated with PD severity, duration, motor and non-motor symptoms, and antiparkinsonian treatment from recent literature. Gut microbial signatures in PD are potential predictors of the disease and are speculated to be used in early diagnosis and treatment. In brief, the review also emphasises on implications of the prebiotic, probiotic, faecal microbiota transplantation, and dietary interventions as alternative treatments in modulating the disease symptoms in PD.
UR - http://www.scopus.com/inward/record.url?scp=85130271298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130271298&partnerID=8YFLogxK
U2 - 10.1007/s12223-022-00977-2
DO - 10.1007/s12223-022-00977-2
M3 - Review article
C2 - 35583791
AN - SCOPUS:85130271298
SN - 0015-5632
VL - 67
SP - 693
EP - 706
JO - Folia Microbiologica
JF - Folia Microbiologica
IS - 5
ER -