TY - JOUR
T1 - Expression of ATOH1 gene and activated signaling pathways for the neurogenesis of cerebellar granule cells
T2 - A review
AU - Poudel, Phanindra Prasad
AU - Bhattarai, Chacchu
AU - Ghosh, Arnab
AU - Kalthur, Sneha Guruprasad
N1 - Funding Information:
The results obtained can be used to design UV radiation sources, as well as devices for protecting fiber systems based on hollow-core fibers, designed to deliver high-power laser radiation, from damage when an optical discharge occurs. In addition, since the propagation velocities of light-detonation (and simply detonation) waves exceeding 100 km/s are realized when an OD moves along hollow optical fibers [3], the results of this work can also be used to simulate experiments on studying the motion of bodies with high speeds. This work was supported by the Russian Science Foundation under Grant #19-12-00361.
Publisher Copyright:
© 2022 by Poudel et al.
PY - 2022
Y1 - 2022
N2 - Granule cells in the cerebellum are derived by the proliferation of cells from the rhombic lips of the metencephalon. Atonal homolog 1 (ATOH1), a protein encoding proneural gene, plays an essential role in the neurogenesis of the cerebellar granule cells. It encodes the basic helix loop helix (bHLH) family of transcription factor ATOH1. Expression of the ATOH1 gene in the rhombic lips of the metencephalon results in specification and proliferation of the granule neuron progenitors. Four major signaling pathways-Sonic hedgehog (Shh), Notch, Wingless related integration site (Wnt) and Bone morphogenetic protein (BMP) play an essential role in the regulation of the ATOH1 gene. Shh, Notch and Wnt signalings induce expression of the ATOH1 gene for the proliferation of the granule neuron progenitors whereas BMP signaling is involved in the differentiation of the granule neuron progenitors into the granule cells. Aberrant expression and mutation of the ATOH1 gene result in cerebellar medulloblastoma, the phenotype of trembling gait, cerebellar ataxia and hearing loss.
AB - Granule cells in the cerebellum are derived by the proliferation of cells from the rhombic lips of the metencephalon. Atonal homolog 1 (ATOH1), a protein encoding proneural gene, plays an essential role in the neurogenesis of the cerebellar granule cells. It encodes the basic helix loop helix (bHLH) family of transcription factor ATOH1. Expression of the ATOH1 gene in the rhombic lips of the metencephalon results in specification and proliferation of the granule neuron progenitors. Four major signaling pathways-Sonic hedgehog (Shh), Notch, Wingless related integration site (Wnt) and Bone morphogenetic protein (BMP) play an essential role in the regulation of the ATOH1 gene. Shh, Notch and Wnt signalings induce expression of the ATOH1 gene for the proliferation of the granule neuron progenitors whereas BMP signaling is involved in the differentiation of the granule neuron progenitors into the granule cells. Aberrant expression and mutation of the ATOH1 gene result in cerebellar medulloblastoma, the phenotype of trembling gait, cerebellar ataxia and hearing loss.
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U2 - 10.31117/neuroscirn.v5i2.125
DO - 10.31117/neuroscirn.v5i2.125
M3 - Short survey
AN - SCOPUS:85130301540
SN - 2576-828X
VL - 5
JO - Neuroscience Research Notes
JF - Neuroscience Research Notes
IS - 2
M1 - 125
ER -