Fabrication and characterization of cefazolin-loaded nanofibrous mats for the recovery of post-surgical wound

Goutam Rath; Taqadus Hussain; Gaurav Chauhan; Tarun Garg; Amit Kumar Goyal

doi:10.3109/21691401.2015.1102741

Fabrication and characterization of cefazolin-loaded nanofibrous mats for the recovery of post-surgical wound

Goutam Rath
, Taqadus Hussain
, Gaurav Chauhan
, Tarun Garg
, Amit Kumar Goyal^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The aim of the present study was to evaluate the wound healing performance of cefazolin-loaded gelatin nanofiber mats in post-operative wound. The obtained nanofibers were smooth, non-beaded and having diameter ranging from 620–680 nm. Nanofiber mats that are prepared exhibit high drug entrapment, excellent oxygen permeability and sustained drug release behavior. Further, medicated nanofiber mats showed an accelerated wound healing as compared to plain cefazolin. Macroscopical and histological evaluations demonstrated that cefazolin-loaded gelatin nanofiber showed increased epithelialization rate and collagen deposition. The results indicated that therapeutic strategies offer new prospects in the management of post-operative wound repair.

Original language	English
Pages (from-to)	1783-1792
Number of pages	10
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	44
Issue number	8
DOIs	https://doi.org/10.3109/21691401.2015.1102741
Publication status	Published - 16-11-2016

All Science Journal Classification (ASJC) codes

Biotechnology
Medicine (miscellaneous)
Biomedical Engineering
Pharmaceutical Science

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10.3109/21691401.2015.1102741

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title = "Fabrication and characterization of cefazolin-loaded nanofibrous mats for the recovery of post-surgical wound",

abstract = "The aim of the present study was to evaluate the wound healing performance of cefazolin-loaded gelatin nanofiber mats in post-operative wound. The obtained nanofibers were smooth, non-beaded and having diameter ranging from 620–680 nm. Nanofiber mats that are prepared exhibit high drug entrapment, excellent oxygen permeability and sustained drug release behavior. Further, medicated nanofiber mats showed an accelerated wound healing as compared to plain cefazolin. Macroscopical and histological evaluations demonstrated that cefazolin-loaded gelatin nanofiber showed increased epithelialization rate and collagen deposition. The results indicated that therapeutic strategies offer new prospects in the management of post-operative wound repair.",

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T1 - Fabrication and characterization of cefazolin-loaded nanofibrous mats for the recovery of post-surgical wound

AU - Rath, Goutam

AU - Hussain, Taqadus

AU - Chauhan, Gaurav

AU - Garg, Tarun

AU - Kumar Goyal, Amit

PY - 2016/11/16

Y1 - 2016/11/16

N2 - The aim of the present study was to evaluate the wound healing performance of cefazolin-loaded gelatin nanofiber mats in post-operative wound. The obtained nanofibers were smooth, non-beaded and having diameter ranging from 620–680 nm. Nanofiber mats that are prepared exhibit high drug entrapment, excellent oxygen permeability and sustained drug release behavior. Further, medicated nanofiber mats showed an accelerated wound healing as compared to plain cefazolin. Macroscopical and histological evaluations demonstrated that cefazolin-loaded gelatin nanofiber showed increased epithelialization rate and collagen deposition. The results indicated that therapeutic strategies offer new prospects in the management of post-operative wound repair.

AB - The aim of the present study was to evaluate the wound healing performance of cefazolin-loaded gelatin nanofiber mats in post-operative wound. The obtained nanofibers were smooth, non-beaded and having diameter ranging from 620–680 nm. Nanofiber mats that are prepared exhibit high drug entrapment, excellent oxygen permeability and sustained drug release behavior. Further, medicated nanofiber mats showed an accelerated wound healing as compared to plain cefazolin. Macroscopical and histological evaluations demonstrated that cefazolin-loaded gelatin nanofiber showed increased epithelialization rate and collagen deposition. The results indicated that therapeutic strategies offer new prospects in the management of post-operative wound repair.

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IS - 8

ER -

Fabrication and characterization of cefazolin-loaded nanofibrous mats for the recovery of post-surgical wound

Abstract

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