Fabrication of a Low Cost Superhydrophobic Substrate for Surface Enhanced Laser-Induced Breakdown Spectroscopy and Its Utility through Identification of Electrolyte Variation for Oral Cancer Detection

Research output: Contribution to journalArticlepeer-review

Abstract

Ultratrace elemental detections from a limited volume of samples can offer significant benefits in biomedical fields. However, it can be challenging to concentrate the particles being analyzed in a small area to improve the accuracy of detection. Ring-like deposits on the edges of colloidal droplets are a vexing problem in many applications. Herein, we report ultratrace elemental detection using a superhydrophobic surface-enhanced laser-induced breakdown spectroscopy (SELIBS) substrate fabricated by laser ablation followed by a soft lithography technique. In this work, the SELIBS spectra on a superhydrophobic polydimethylsiloxane (PDMS) substrate replicated from a laser-patterned master Teflon substrate are investigated. This work highlights the application of this newly created superhydrophobic substrate for detecting trace elements in body fluids using SELIBS. The developed PDMS substrate was successfully adopted to investigate the electrolyte variation in serum samples of oral cancer patients and normal volunteers. Principal component analysis (PCA) and match-no-match analysis were used to distinguish the elemental variation in cancer and control groups.

Original languageEnglish
JournalACS Biomaterials Science and Engineering
DOIs
Publication statusAccepted/In press - 2023

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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