TY - JOUR
T1 - Factors associated with mortality due to neonatal pneumonia in India
T2 - A protocol for systematic review and planned meta-analysis
AU - Nair, N. Sreekumaran
AU - Lewis, Leslie Edward
AU - Lakiang, Theophilus
AU - Godinho, Myron
AU - Murthy, Shruti
AU - Venkatesh, Bhumika T.
N1 - Funding Information:
funding This project is supported by a grant from Bill and Melinda Gates Foundation (grantOPP1084307) to The INCLEN Trust International and sub-grant to Manipal University(subgrant INC2015GNT004). The views expressed through this project do not necessarilyrepresent the views of Bill and Melinda Gates Foundation or The INCLEN Trust Internationalor Manipal University. competing interests All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: all authors had financial support (grants) from Bill and Melinda Gates Foundation (grant OPP1084307) to The INCLEN Trust International and sub-grant to Manipal University (subgrant INC2015GNT004)., during the conduct of the study and for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years;no other relationships or activities that could appear to have influenced the submitted work.
Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Introduction India contributes to the highest number of neonatal deaths globally. It also has the greatest number of pneumonia-related neonatal deaths in the developing world. We aim to systematically review the evidence for the factors associated with mortality due to neonatal pneumonia in the Indian context, to address the lack of consolidated evidence on this important issue. Methods and analysis This protocol is part of a series of three reviews on neonatal pneumonia in India. Observational studies reporting on outcome of neonatal pneumonia in the Indian context, and published in English in peer-reviewed and indexed journals will be eligible for inclusion. Outcomes of this review will be the factors determining mortality due to neonatal pneumonia. A total of nine databases will be searched. Electronic and hand searching of published and grey literature will be performed. Selection of studies will be done in title, abstract and full text screening stages. Risk of bias, independently assessed by two authors, will be evaluated. Meta-analysis will be performed and heterogeneity assessed. Pooled effect estimates will be stated with 95% confidence intervals. Narrative synthesis will be done where meta-analysis cannot be performed. Publication bias will be evaluated and sensitivity analysis performed according to study quality. Quality of this review will be evaluated using AMSTAR (Assessing the Methodological quality of Systematic Reviews) and GRADE (Grades of Recommendation, Assessment, Development & Evaluation). A summary of findings table will be reported using GRADEPro. Ethics and dissemination Since this is a review involving analysis of secondary data which is available in the public domain, and does not involve human participants, ethical approval was not required. The findings of the study will be shared with all stakeholders of this research. Knowledge dissemination workshops will be conducted with relevant stakeholders to transfer the evidence, tailored to the stakeholder (eg, policy briefs, publications, information booklets, etc).
AB - Introduction India contributes to the highest number of neonatal deaths globally. It also has the greatest number of pneumonia-related neonatal deaths in the developing world. We aim to systematically review the evidence for the factors associated with mortality due to neonatal pneumonia in the Indian context, to address the lack of consolidated evidence on this important issue. Methods and analysis This protocol is part of a series of three reviews on neonatal pneumonia in India. Observational studies reporting on outcome of neonatal pneumonia in the Indian context, and published in English in peer-reviewed and indexed journals will be eligible for inclusion. Outcomes of this review will be the factors determining mortality due to neonatal pneumonia. A total of nine databases will be searched. Electronic and hand searching of published and grey literature will be performed. Selection of studies will be done in title, abstract and full text screening stages. Risk of bias, independently assessed by two authors, will be evaluated. Meta-analysis will be performed and heterogeneity assessed. Pooled effect estimates will be stated with 95% confidence intervals. Narrative synthesis will be done where meta-analysis cannot be performed. Publication bias will be evaluated and sensitivity analysis performed according to study quality. Quality of this review will be evaluated using AMSTAR (Assessing the Methodological quality of Systematic Reviews) and GRADE (Grades of Recommendation, Assessment, Development & Evaluation). A summary of findings table will be reported using GRADEPro. Ethics and dissemination Since this is a review involving analysis of secondary data which is available in the public domain, and does not involve human participants, ethical approval was not required. The findings of the study will be shared with all stakeholders of this research. Knowledge dissemination workshops will be conducted with relevant stakeholders to transfer the evidence, tailored to the stakeholder (eg, policy briefs, publications, information booklets, etc).
UR - http://www.scopus.com/inward/record.url?scp=85029104556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029104556&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2017-017616
DO - 10.1136/bmjopen-2017-017616
M3 - Article
AN - SCOPUS:85029104556
SN - 2044-6055
VL - 7
JO - BMJ Open
JF - BMJ Open
IS - 9
M1 - e017616
ER -
