Feasibility and Safety of Accelerated Sequential Theta Burst Stimulation for Adolescent Obsessive-compulsive Disorder: A Case Report

Jithin Thekkelkuthiyathottil Joseph; Ashok Jammigumpula; Anjali Prakash; Amrtavarshini Radhakrishna; Jithin Jaise; Prathvi Naik; Abhiram N. Purohith; Sonia Shenoy; Samir Kumar Praharaj

doi:10.1177/09731342241267114

Feasibility and Safety of Accelerated Sequential Theta Burst Stimulation for Adolescent Obsessive-compulsive Disorder: A Case Report

Jithin Thekkelkuthiyathottil Joseph
, Ashok Jammigumpula
, Anjali Prakash
, Amrtavarshini Radhakrishna
, Jithin Jaise
, Prathvi Naik
, Abhiram N. Purohith
, Sonia Shenoy
, Samir Kumar Praharaj

Department of Psychiatry, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been shown to be effective for treatment-resistant obsessive-compulsive disorder (OCD) in adults; however, it has not yet been studied in adolescents with OCD. This report details the feasibility and safety of administering sequential accelerated theta burst stimulation (sequential aTBS) in an adolescent with treatment-resistant OCD. Despite completing 29 continuous TBS sessions over the right dorsolateral prefrontal cortex (DLPFC) and an additional 15 intermittent TBS sessions on the left DLPFC, our patient did not show any symptom improvement. This case represents the first documentation of the feasibility, safety, and tolerability of sequential aTBS in adolescents with OCD. The patient tolerated the aTBS sessions well, experiencing only mild tingling and local muscle twitches.

Original language	English
Pages (from-to)	190-192
Number of pages	3
Journal	Journal of Indian Association for Child and Adolescent Mental Health
Volume	21
Issue number	2
DOIs	https://doi.org/10.1177/09731342241267114
Publication status	Published - 01-04-2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Psychiatry and Mental health

Access to Document

10.1177/09731342241267114

Cite this

Joseph, J. T., Jammigumpula, A., Prakash, A., Radhakrishna, A., Jaise, J., Naik, P., Purohith, A. N., Shenoy, S., & Praharaj, S. K. (2025). Feasibility and Safety of Accelerated Sequential Theta Burst Stimulation for Adolescent Obsessive-compulsive Disorder: A Case Report. Journal of Indian Association for Child and Adolescent Mental Health, 21(2), 190-192. https://doi.org/10.1177/09731342241267114

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title = "Feasibility and Safety of Accelerated Sequential Theta Burst Stimulation for Adolescent Obsessive-compulsive Disorder: A Case Report",

abstract = "Repetitive transcranial magnetic stimulation (rTMS) has been shown to be effective for treatment-resistant obsessive-compulsive disorder (OCD) in adults; however, it has not yet been studied in adolescents with OCD. This report details the feasibility and safety of administering sequential accelerated theta burst stimulation (sequential aTBS) in an adolescent with treatment-resistant OCD. Despite completing 29 continuous TBS sessions over the right dorsolateral prefrontal cortex (DLPFC) and an additional 15 intermittent TBS sessions on the left DLPFC, our patient did not show any symptom improvement. This case represents the first documentation of the feasibility, safety, and tolerability of sequential aTBS in adolescents with OCD. The patient tolerated the aTBS sessions well, experiencing only mild tingling and local muscle twitches.",

author = "Joseph, \{Jithin Thekkelkuthiyathottil\} and Ashok Jammigumpula and Anjali Prakash and Amrtavarshini Radhakrishna and Jithin Jaise and Prathvi Naik and Purohith, \{Abhiram N.\} and Sonia Shenoy and Praharaj, \{Samir Kumar\}",

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Joseph, JT, Jammigumpula, A, Prakash, A, Radhakrishna, A, Jaise, J, Naik, P, Purohith, AN, Shenoy, S & Praharaj, SK 2025, 'Feasibility and Safety of Accelerated Sequential Theta Burst Stimulation for Adolescent Obsessive-compulsive Disorder: A Case Report', Journal of Indian Association for Child and Adolescent Mental Health, vol. 21, no. 2, pp. 190-192. https://doi.org/10.1177/09731342241267114

Feasibility and Safety of Accelerated Sequential Theta Burst Stimulation for Adolescent Obsessive-compulsive Disorder: A Case Report. / Joseph, Jithin Thekkelkuthiyathottil; Jammigumpula, Ashok; Prakash, Anjali et al.
In: Journal of Indian Association for Child and Adolescent Mental Health, Vol. 21, No. 2, 01.04.2025, p. 190-192.

Research output: Contribution to journal › Article › peer-review

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AU - Jammigumpula, Ashok

AU - Prakash, Anjali

AU - Radhakrishna, Amrtavarshini

AU - Jaise, Jithin

AU - Naik, Prathvi

AU - Purohith, Abhiram N.

AU - Shenoy, Sonia

AU - Praharaj, Samir Kumar

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AB - Repetitive transcranial magnetic stimulation (rTMS) has been shown to be effective for treatment-resistant obsessive-compulsive disorder (OCD) in adults; however, it has not yet been studied in adolescents with OCD. This report details the feasibility and safety of administering sequential accelerated theta burst stimulation (sequential aTBS) in an adolescent with treatment-resistant OCD. Despite completing 29 continuous TBS sessions over the right dorsolateral prefrontal cortex (DLPFC) and an additional 15 intermittent TBS sessions on the left DLPFC, our patient did not show any symptom improvement. This case represents the first documentation of the feasibility, safety, and tolerability of sequential aTBS in adolescents with OCD. The patient tolerated the aTBS sessions well, experiencing only mild tingling and local muscle twitches.

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Feasibility and Safety of Accelerated Sequential Theta Burst Stimulation for Adolescent Obsessive-compulsive Disorder: A Case Report

Abstract

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