Formation of substituted propanenitrile during biginelli type reaction of tosyloxy benzaldehyde with malononitrile: Synthesis and crystal structure determination

Shubhalaxmi; C. S. Chidan Kumar; Hoong Kun Fun; K. Subrahmanya Bhat

Formation of substituted propanenitrile during biginelli type reaction of tosyloxy benzaldehyde with malononitrile: Synthesis and crystal structure determination

Shubhalaxmi, C. S. Chidan Kumar, Hoong Kun Fun, K. Subrahmanya Bhat

Research output: Contribution to journal › Article › peer-review

Abstract

Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies.

Original language	English
Pages (from-to)	1228-1233
Number of pages	6
Journal	Research Journal of Pharmaceutical, Biological and Chemical Sciences
Volume	6
Issue number	3
Publication status	Published - 01-01-2015

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Formation of substituted propanenitrile during biginelli type reaction of tosyloxy benzaldehyde with malononitrile: Synthesis and crystal structure determination",

abstract = "Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies.",

author = "Shubhalaxmi and {Chidan Kumar}, {C. S.} and Fun, {Hoong Kun} and {Subrahmanya Bhat}, K.",

year = "2015",

month = jan,

day = "1",

language = "English",

volume = "6",

pages = "1228--1233",

journal = "Research Journal of Pharmaceutical, Biological and Chemical Sciences",

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Formation of substituted propanenitrile during biginelli type reaction of tosyloxy benzaldehyde with malononitrile: Synthesis and crystal structure determination. / Shubhalaxmi; Chidan Kumar, C. S.; Fun, Hoong Kun et al.
In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 6, No. 3, 01.01.2015, p. 1228-1233.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Formation of substituted propanenitrile during biginelli type reaction of tosyloxy benzaldehyde with malononitrile

T2 - Synthesis and crystal structure determination

AU - Shubhalaxmi,

AU - Chidan Kumar, C. S.

AU - Fun, Hoong Kun

AU - Subrahmanya Bhat, K.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies.

AB - Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies.

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UR - http://www.scopus.com/inward/citedby.url?scp=84938767259&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84938767259

SN - 0975-8585

VL - 6

SP - 1228

EP - 1233

JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences

JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences

IS - 3

ER -

Formation of substituted propanenitrile during biginelli type reaction of tosyloxy benzaldehyde with malononitrile: Synthesis and crystal structure determination

Abstract

All Science Journal Classification (ASJC) codes

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