TY - JOUR
T1 - Formulation and characterisation of lacidipine niosomal gel for transdermal delivery
AU - Mapari, Salika Santosh
AU - Mary Dcruz, Cleona Elizabeth
AU - Kumar, Lalit
AU - Bhide, Prashant Jivaji
AU - Shirodkar, Rupesh Kalidas
N1 - Funding Information:
The authors are thankful to All India Council for Technical Education (AICTE), New Delhi, India for financial support. The authors are also thankful to Goa College of Pharmacy, Panaji, Goa and Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal for providing infrastructural facilities to complete this work.
Publisher Copyright:
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2023/3
Y1 - 2023/3
N2 - The present study aimed to enhance the transdermal delivery of lacidipine by niosomal vesicles. Lacidipine niosomes were generated using the ultrasonic method, and Span 60 was used as a nonionic surfactant. Formulations were prepared containing Span 60 and cholesterol in 1:1 and 2:1 ratios, respectively, with essential oils added at increasing concentrations. The formulated niosomes had nano-vesicles with entrapment efficiency ranging from 75.81% to 91.25% and in-vitro drug release ranging from 80.61% to 89.81%. The optimal formulation was selected based on particle size, entrapment efficiency and in-vitro drug release. Optical microscopy and high-resolution transmission electron microscopy studies revealed a spherical shape of the niosomal vesicles. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction studies confirmed complete encapsulation of the drug in the niosomal vesicles. The optimized formulation was also incorporated into a gel base, which was then evaluated for appearance, pH, viscosity, spreadability, in vitro drug release and stability. Overall, the results indicated that the developed niosomal lacidipine vesicles may provide an alternative to existing delivery systems for this drug.
AB - The present study aimed to enhance the transdermal delivery of lacidipine by niosomal vesicles. Lacidipine niosomes were generated using the ultrasonic method, and Span 60 was used as a nonionic surfactant. Formulations were prepared containing Span 60 and cholesterol in 1:1 and 2:1 ratios, respectively, with essential oils added at increasing concentrations. The formulated niosomes had nano-vesicles with entrapment efficiency ranging from 75.81% to 91.25% and in-vitro drug release ranging from 80.61% to 89.81%. The optimal formulation was selected based on particle size, entrapment efficiency and in-vitro drug release. Optical microscopy and high-resolution transmission electron microscopy studies revealed a spherical shape of the niosomal vesicles. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction studies confirmed complete encapsulation of the drug in the niosomal vesicles. The optimized formulation was also incorporated into a gel base, which was then evaluated for appearance, pH, viscosity, spreadability, in vitro drug release and stability. Overall, the results indicated that the developed niosomal lacidipine vesicles may provide an alternative to existing delivery systems for this drug.
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U2 - 10.1515/tsd-2022-2439
DO - 10.1515/tsd-2022-2439
M3 - Article
AN - SCOPUS:85149893268
SN - 0932-3414
VL - 60
SP - 124
EP - 139
JO - Tenside, Surfactants, Detergents
JF - Tenside, Surfactants, Detergents
IS - 2
ER -