Formulation and characterization of soya lecithin-based liposomes for encapsulating a weakly soluble Naringenin

Naringenin is prominent citrus flavonoids that are found mostly in grapes and oranges. It has long been thought to be a helpful therapeutic agent, but its usage has been limited due to its poor water solubility and bioavailability. The goal of this study was to improve naringenin bioavailability and therapeutic efficacy utilization by innovative liposome formulations created using the thin lipid film technique using soya lecithin and cholesterol as surface modifiers. The liposome that was successfully formulated (F3) was spherical in shape, and had a regulated release profile in-vitro. The tiny particle size (100 nm), high encapsulation efficiency (>88%), and drug loading capacity (>94%) revealed that naringenin and the liposome core had a strong affinity. Release kinetics models such as zero order, first order, Higuchi, and Peppas are constantly used to predict drug release profiles in order to develop a better in vitro-in vivo association. The majority of these models rely on diffusion equations based on liposome composition and release conditions. The drug release from the formulation follows zero order kinetics, according to the correlation coefficient values (R²) derived from several models. When tested with the Korsmeyer-peppas model, all of the formulations were linear. The erosion and swelling of the polymer dominated the drug release. The release exponent in the Korsmeyer-peppas model suggests that the process win drug release is a case II super transport. Based on these observations, it was anticipated that liposomal formulations could be useful nanocarriers for bypassing the oral delivery constraint of hydrophobic substances.