Formulation and evaluation of methotrexate niosomes

N. Udupa; K. S. Chandraprakash; P. Umadevi; G. K. Pillai

doi:10.3109/03639049309074404

Formulation and evaluation of methotrexate niosomes

N. Udupa, K. S. Chandraprakash, P. Umadevi, G. K. Pillai

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Methotrexate was encapsulated in niosomes prepared using Tweens and Spans. The size distribution, entrapment efficiency, pharmacokinetics and effect on tumour remission of mice transplanted with S-180 Sarcoma were evaluated. Niosomes prepared with Span 60 gave promising results.

Original language	English
Pages (from-to)	1331-1342
Number of pages	12
Journal	Drug Development and Industrial Pharmacy
Volume	19
Issue number	11
DOIs	https://doi.org/10.3109/03639049309074404
Publication status	Published - 01-01-1993

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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title = "Formulation and evaluation of methotrexate niosomes",

abstract = "Methotrexate was encapsulated in niosomes prepared using Tweens and Spans. The size distribution, entrapment efficiency, pharmacokinetics and effect on tumour remission of mice transplanted with S-180 Sarcoma were evaluated. Niosomes prepared with Span 60 gave promising results.",

author = "N. Udupa and Chandraprakash, {K. S.} and P. Umadevi and Pillai, {G. K.}",

year = "1993",

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T1 - Formulation and evaluation of methotrexate niosomes

AU - Udupa, N.

AU - Chandraprakash, K. S.

AU - Umadevi, P.

AU - Pillai, G. K.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Methotrexate was encapsulated in niosomes prepared using Tweens and Spans. The size distribution, entrapment efficiency, pharmacokinetics and effect on tumour remission of mice transplanted with S-180 Sarcoma were evaluated. Niosomes prepared with Span 60 gave promising results.

AB - Methotrexate was encapsulated in niosomes prepared using Tweens and Spans. The size distribution, entrapment efficiency, pharmacokinetics and effect on tumour remission of mice transplanted with S-180 Sarcoma were evaluated. Niosomes prepared with Span 60 gave promising results.

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U2 - 10.3109/03639049309074404

DO - 10.3109/03639049309074404

M3 - Article

AN - SCOPUS:0027154886

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EP - 1342

JO - Drug Development and Industrial Pharmacy

JF - Drug Development and Industrial Pharmacy

IS - 11

ER -

Formulation and evaluation of methotrexate niosomes

Abstract

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