Transdermal patches of metoclopramide hydrochloride were prepared using polyvinylalcohol and polyvinylpyrrolidone for the treatment of vomiting and nausea. The physicochemical parameters like thickness, drug content, weight variation, moisture content, moisture uptake and drug permeation studies (through dialysis sac and rat skin) were evaluated for the prepared patches. The formulations exhibited uniform thickness and weight, good drug content and little moisture content and uptake. In the in vitro drug permeation studies, the formulations showed burst release of the drug in initial hours and thereafter drug was released slowly upto 12 h. The drug release mechanism from the patches was found to be diffusion dominated. The stability studies indicated that all patches maintained good physical appearance and drug content for 6 months at 40°/75% RH.
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|Published - 2006