@article{01670909d2f44791ae3c2435f1303fd2,
title = "Formulation and evaluation of transdermal patches of metoclopramide hydrochloride",
abstract = "Transdermal patches of metoclopramide hydrochloride were prepared using polyvinylalcohol and polyvinylpyrrolidone for the treatment of vomiting and nausea. The physicochemical parameters like thickness, drug content, weight variation, moisture content, moisture uptake and drug permeation studies (through dialysis sac and rat skin) were evaluated for the prepared patches. The formulations exhibited uniform thickness and weight, good drug content and little moisture content and uptake. In the in vitro drug permeation studies, the formulations showed burst release of the drug in initial hours and thereafter drug was released slowly upto 12 h. The drug release mechanism from the patches was found to be diffusion dominated. The stability studies indicated that all patches maintained good physical appearance and drug content for 6 months at 40°/75% RH.",
author = "M. Saxena and S. Mutalik and M.S. Reddy",
note = "Cited By :21 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Reddy, M. S.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal-576 104, Karnataka, India; email: ms.reddy@manipal.edu References: Tripathi, K.D., Emetics, Antiemetics and other gastrointestinal drugs (2003) Pharmacology, p. 599. , 5th Edn., Jaypee Publishers, New Delhi; Vyas, S.P., Khar, R.K., Transdermal Drug Delivery (2002) Controlled Drug Delivery Concepts and Advances, p. 411. , 2nd Edn., Jaypee Publishers, New Delhi; Martin, A., Swarbrick, J., Camnarata, A., Kinetics (1993) Physical Pharmacy-Physical Chemical Principles in the Pharmaceutical Sciences, p. 284. , 4th Edn., Lea and Febiger, Philadelphia, USA; Hui, H.W., Lee, V.H.L., Robinson, J.R., Design and fabrication of oral controlled release systems (1987) Fundamentals of Controlled Drug Delivery Systems, p. 373. , Marcel Dekker Inc., New York, USA; Korsmeyer, R.W., Gurny, R., Doelker, E., Buri, P., Peppas, N.A., Mechanism of solute release from porous hydrophilic polymers (1983) Int. J. Pharm., 15, p. 25; Arora, P., Mukherjee, B., Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt (2003) J. Pharm. Sci., 91, p. 2076; Kim, D.D., Chein, Y.W., Simultaneous skin permeation of di-deoxynucleoside type anti HIV drugs (1996) J. Control. Rel., 40, p. 67; Kanikkannan, N., Formulation and in vitro evaluation of transdermal patches of melatoin (2004) Drug Dev. Ind. Pharm., 30, p. 205; Piemi, M.P.Y., Transdermal delivery of glucose through hairless rat skin in vitro: Effect of multiple and simple emulsions (1998) Int. J. Pharm., 171, p. 207",
year = "2006",
language = "English",
volume = "43",
pages = "740--745",
journal = "Indian Drugs",
issn = "0019-462X",
publisher = "Indian Drug Manufacturers' Association",
number = "9",
}