Formulation and evaluation of zaltoprofen immediate release tablets using superdisintegrants

The aim present work is Formulate and Evaluate the Immediate release tablets of Zaltoprofen. Zaltoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used as an analgesic, antipyretic, and anti-inflammatory agent. Hence in this investigation an attempt was made to develop oral disintegrating tablets of Zaltoprofen with super disintegrating agents like Explotab, Primojel, Solutab were used to super diintegrants, The superdisintegrants were taken in different ratios. The formulations were prepared by direct compression technique, Taste masking was done by Sweetning agent. As a result of the studies, the blend of all formulations showed good flow properties such as angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio. The prepared tablets were shown good post compression parameters a like Hardness, Thickness, weigh variation, friability, Content uniformity, disintegration time, In vitro dissolution studies. The FTIR studies all the excipients are tested for compatibility with drug, which revealed that there was no physical and chemical interaction occurred. The drug release rate from tablets was studied using the USP type ΙΙ dissolution test apparatus. The dissolution medium was 900 ml of pH 6.8 phosphate buffer at 50 rpm at a temperature of 37±0.5 ˚C. The formulation F8 consisting of Solutab was found be best among all the formulations it has exhibited faster disintegrating time (2 min) when compared to other formulations and it showed 99.56 % drug release in 30min.