Formulation development and evaluation of glyburide beads for controlled release

Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the advantages of oral route of drug administration. In certain conditions conventional drug release pattern is not suitable like Diabetes mellitus, Asthma, cardiovascular diseases Arthritis, Peptic ulcer etc. this present study an attempt was made to formulate controlled release beads of Glyburide by using Sodium alginate, HPMC K100M, Carbopol 940 and Calcium Chloride(fused).Beads were successfully prepared by Ionotropic Gelation Method. The prepared beads evaluated for various parameters lke encapsulation efficacy, swelling index, Mean particle size, flow properties and in vitro release. The yields were varies from 88-93.8% and encapsulation efficacy is up to 91.2% which encourage the investigation. The in-vitro dissolution profile of optimized formulation batch i.e., F4 is resulted up 12 hours. The various parameters of model equation of beads containing Glyburide in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi and Korsmeyer- Peppas model. To establish the release kinetic, Korsmeyer- Peppas model shows the prominent release characteristics.