Formulation, Release Characteristics and Evaluation of Nimesulide Suppositories

Mohammed Gulzar Ahmed, Venkatesh, G. Khaksa, N. Udupa, K. L.K. Paranjyothy

Research output: Contribution to journalArticlepeer-review

5 Citations (SciVal)


Suppositories of nimesulide were formulated using cocoa butter and different polyethylene glycol (PEG) bases. PEG base suppositories showed a better permeation of drug with faster dissolution rate in vitro than cocoa butter base suppositories. The results of in vivo antiinflammatory activity of nimesulide suppositories in Wistar rats showed that suppositories of cocoa butter base exhibited better antiinflammatory activity than PEG bases.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Issue number3
Publication statusPublished - 05-2000

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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