Abstract
Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin, bisdemethoxycurcumin) and acetylcurcumin were compared for their ability to scavenge superoxide radicals and to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radicals. The results showed that curcumin is the most potent scavenger of superoxide radicals followed by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was inactive. Interaction with DPPH showed a similar activity profile. The study indicates that the phenolic group is essential for the free radical scavenging activity and presence of methoxy group further increases the activity.
Original language | Undefined/Unknown |
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Pages (from-to) | 169-171 |
Number of pages | 3 |
Journal | Arzneimittel-Forschung/Drug Research |
Volume | 46 |
Issue number | 2 |
Publication status | Published - 1996 |