Abstract
Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin, bisdemethoxycurcumin) and acetylcurcumin were compared for their ability to scavenge superoxide radicals and to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radicals. The results showed that curcumin is the most potent scavenger of superoxide radicals followed by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was inactive. Interaction with DPPH showed a similar activity profile. The study indicates that the phenolic group is essential for the free radical scavenging activity and presence of methoxy group further increases the activity.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 169-171 |
| Number of pages | 3 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 46 |
| Issue number | 2 |
| Publication status | Published - 1996 |