TY - JOUR
T1 - Free radical scavenging and nephroprotective activity of Hybanthus enneaspermus (L) F.Muell
AU - Manjunath Setty, M.
AU - Narayanaswamy, V.B.
AU - Sreenivasan, K.K.
AU - Shirwaikar, A.
N1 - Cited By :4
Export Date: 10 November 2017
Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: [email protected]
Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; alcohol, 64-17-5; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; creatinine, 19230-81-0, 60-27-5; ferric ion, 20074-52-6; glutathione, 70-18-8; glutathione transferase, 50812-37-8; lipid, 66455-18-3; nitric oxide, 10102-43-9; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; urea, 57-13-6
Manufacturers: Bio chem, India
References: Singh NP. In: Flora of Eastern Karnataka, I, 1st edn., Mittal Publications, Delhi,1988; 141-142Majumder PL, Basu A, Mal D. Chemical constituents of Hybanthus enneaspermus. Ind. J. Chem 1979; 17B, 297-298; Yoganarasimhan SN. In: Medicinal Plants of India-Tamilnadu, II, Cyber Media, Bangalore, 2000; 276; Kirtikar, K.R., Basu, B.D., (1991) Indian Medicinal Plants, 1, pp. 212-213. , 2nd ed, Periodical Experts Book Agency, Delhi; Rajakaruna, N., Harris, C.S., Towers, G.H.N., Antimicrobial activity of plants collected from Serpentine outcrops in Sri Lanka (2002) Pharm Biol, 40, pp. 235-244; Weniger, B., Lagnika, L., Vonthron-Senecheau, C., Adjobimey, T., Gbenou, J., Moudachirou, (2004) J Ethnopharmacol, 90, pp. 279-284; Majumdar, P.L., Basu, A., Mal, D., Chemical constituents of Hybanthus enneaspermus (1979) Ind J Chem, 17 B, pp. 297-298; Prakash, E., Sha Valli Khan, P.S., Sairam Reddy, P., Rao, K.R., Regeneration of plants from seed derived callus of Hybanthus enneaspermus (L) Muell, a rare ethnobotanical herb (1999) Plant Cell Rep, 18, pp. 873-878; Retnam, K.R., De Britto, A.J., Phytochemical analysis of a medicinal plant Hybanthus enneaspermus (L) F. Muell (2003) J Econ Taxon Bot, 27 (PART3), pp. 701-706; Sreejayan, N., Rao, M.N.A., Free radical scavenging activity of curcuminoids (1996) Drug Research, 46, p. 169; Sreejayan, N., Rao, M.N.A., Nitric oxide scavenging by curcuminoids (1997) J Pharm Pharmacology, 49, p. 105; Miller, N.J., Rice, C.A., Total antioxidant status in plasma and body fluids (1994) Methods in enzymology, 234, p. 279; Rajakumar, D.V., Rao, M.N.A., Antioxidant properties of Dehydrozingerone and Curcumin in rat brain homogenates (1994) Molecular and Cellular Biochemistry, 140, pp. 73-79; Ghosh, M.N., (1984) Fundamentals of experimental pharmacology, , Published by Scientific book agency, Calcutta; Greggi, A.L.M., Darin, J.D., Bianchi, M.D., Protective effects of vitamin C against cisplatin induced nephrotoxicity and lipid peroxidation in adult rats: A dose dependent study (2000) Pharmacology Research, 41 (4), pp. 405-411; Varley, H., Alan, H.G., (1980) Text book of Clinical Biochemistry, , 15th edn, published by William Heinemann Medical Book, Landon; Mannervik, B., Glutathione peroxides (1985) Methods in Enzymology, 113, pp. 490-495; Habig, W.H., Papst, M.J., Jacoby, W.B., (1974) J of Biochemistry, 299, pp. 7130-7139; Uchiyama, M., Mihara, M., Determination of malonaldehyde precursor in tissues by thiobaruturic acid test (1978) Analytica Biochemistry, 86, pp. 271-272; Winterbourn, G., Hawkins, R., Brian, M., Estimations of red cells SOD activity (1975) J Lab Cli Med, 85, p. 337
PY - 2007
Y1 - 2007
N2 - The plant Hybanthus enneaspermus have been widely used traditionally to treat variety of common and stress related disorders. In the present investigation, the ethanol and aqueous extracts of Hybanthus enneaspermus were studied for its nephroprotective activity in cisplatin induced renal injury in rats. The extracts at dose levels of 250 and 500mg/kg showed dose- dependent reduction in the elevated blood urea and serum creatinine. Treatment with the alcoholic and aqueous extracts of Hybanthus enneaspermus increased GSH, GST and SOD level and inhibited the lipid peroxidation induced by cisplatin in the kidney homogenate. Cisplatin administration resulted in increased blood urea and serum creatinine levels which were reversed by the alcoholic and aqueous extracts of Hybanthus enneaspermus. The results suggest that the alcoholic and aqueous extracts of the Hybanthus enneaspermus possesses significant curative and preventive nephroprotective activity. Furthermore, the extract was studied for free radical scavenging potential to correlate its nephroprotective activity.
AB - The plant Hybanthus enneaspermus have been widely used traditionally to treat variety of common and stress related disorders. In the present investigation, the ethanol and aqueous extracts of Hybanthus enneaspermus were studied for its nephroprotective activity in cisplatin induced renal injury in rats. The extracts at dose levels of 250 and 500mg/kg showed dose- dependent reduction in the elevated blood urea and serum creatinine. Treatment with the alcoholic and aqueous extracts of Hybanthus enneaspermus increased GSH, GST and SOD level and inhibited the lipid peroxidation induced by cisplatin in the kidney homogenate. Cisplatin administration resulted in increased blood urea and serum creatinine levels which were reversed by the alcoholic and aqueous extracts of Hybanthus enneaspermus. The results suggest that the alcoholic and aqueous extracts of the Hybanthus enneaspermus possesses significant curative and preventive nephroprotective activity. Furthermore, the extract was studied for free radical scavenging potential to correlate its nephroprotective activity.
M3 - Article
SN - 1827-8620
VL - 2
SP - 158
EP - 171
JO - Pharmacologyonline
JF - Pharmacologyonline
ER -