TY - JOUR
T1 - Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study
AU - Kumar, Kiran T.
AU - Chandrika, A.
AU - Sumanth, Krishna N.
AU - Sireesha, P.
AU - Rao, Suryanarayana
AU - Rao, Anjali
PY - 2004/8/16
Y1 - 2004/8/16
N2 - Background. The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a vast array of disease processes including some neurological disorders. Method. Ten patients with Guillain-Barre syndrome (GBS) and 10 age and sex-matched controls were included in this study. The erythrocyte glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) levels, as well as plasma antioxidant vitamins C and E and serum glutathione-S-transferase (GST) levels were estimated spectrophotometrically. Results. The plasma vitamin E and the serum total glutathione-S-transferase levels were markedly increased in both pre- and post-treated cases of GBS when compared to controls. The erythrocyte glutathione and malondialdehyde levels were significantly reduced in GBS cases when compared to normals. However, plasma vitamin C and erythrocyte superoxide dismutase were not altered when compared to controls. Conclusion. Free radical toxicity may have an influence in patients suffering from GBS.
AB - Background. The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a vast array of disease processes including some neurological disorders. Method. Ten patients with Guillain-Barre syndrome (GBS) and 10 age and sex-matched controls were included in this study. The erythrocyte glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) levels, as well as plasma antioxidant vitamins C and E and serum glutathione-S-transferase (GST) levels were estimated spectrophotometrically. Results. The plasma vitamin E and the serum total glutathione-S-transferase levels were markedly increased in both pre- and post-treated cases of GBS when compared to controls. The erythrocyte glutathione and malondialdehyde levels were significantly reduced in GBS cases when compared to normals. However, plasma vitamin C and erythrocyte superoxide dismutase were not altered when compared to controls. Conclusion. Free radical toxicity may have an influence in patients suffering from GBS.
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U2 - 10.1016/j.cccn.2004.03.032
DO - 10.1016/j.cccn.2004.03.032
M3 - Article
C2 - 15256322
AN - SCOPUS:3142570442
SN - 0009-8981
VL - 346
SP - 205
EP - 209
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 2
ER -