@article{84d130cfa750488aa7fe808986150c00,
title = "From thalidomide to rofecoxib: Can we afford to wait and watch?",
abstract = "Drug safety constitutes the cornerstone of modern therapeutics. Nowadays, the focus tends to be more on the hazards of drugs rather than on their benefits. This article describes from a healthcare professional's viewpoint the history behind two major drug disasters: thalidomide and rofecoxib and the reasons why drug withdrawals continue, taking the classic example of rofecoxib despite our safety concerns and the method to overcome those disasters in the future. The paper highlights the major steps to be followed for pharmacovigilance as an effective component of drug safety. The responsibility of healthcare professionals has ultimately to do with patient care and is to promote a culture of safe and efficacious drug use and thereby preventing future disasters related to modern therapeutics. {\textcopyright} 2006 - IOS Press and the authors. All rights reserved.",
author = "S.A. Khan and P.G.M. Rao and G.S. Rodrigues and S. Rajan and A. Heda",
note = "Cited By :7 Export Date: 10 November 2017 CODEN: IJMDE Correspondence Address: Khan, S.A.; Department of Pharmacy Practice, S S Cancer Hospital, Research Centre, Manipal 576 104, Karnataka State, India; email: sohailkhan1981@gmail.com Chemicals/CAS: althesin, 8067-82-1; benoxaprofen, 51234-28-7; celecoxib, 169590-42-5; centoxin, 138330-99-1; diclofenac, 15307-79-6, 15307-86-5; dilevalol, 75659-07-3; fenclofenac, 34645-84-6; feprazone, 30748-29-9; ibuprofen, 15687-27-1; indometacin, 53-86-1, 74252-25-8, 7681-54-1; indoprofen, 31842-01-0; metipranolol, 22664-55-7; naproxen, 22204-53-1, 26159-34-2; nomifensine maleate, 32795-47-4; pemoline, 2152-34-3; perhexiline maleate, 6724-53-4; practolol, 6673-35-4; remoxipride, 78810-02-3, 80125-14-0, 82935-42-0; rofecoxib, 162011-90-7, 186912-82-3; sertindole, 106516-24-9; suprofen, 40828-46-4; temafloxacin, 105784-61-0, 108319-06-8; terodiline, 15793-40-5, 7082-21-5; thalidomide, 50-35-1; tolcapone, 134308-13-7; triazolam, 28911-01-5; zimeldine, 56775-88-3, 60525-15-7; zomepirac, 33369-31-2, 64092-48-4 Tradenames: althesin; centoxin; eraldin; flenac; flosint; glauline; halcion; merital; methrazone; micturin; opren; osmosin; pexid; roxiam; serdolect; suprol; tasmar; teflox; unicard; vioxx; volital; zelmid; zomepirac Manufacturers: Pfizer References: Andersohn, F., Suissa, S., Garbe, E., Use of first- And second-generation cyclooxygenase-2-selective nonsteroidal antiinflammatory drugs and risk of acute myocardial infarction (2006) Circulation, , Apr. 17; [Epub ahead of print]; Bakr, M., Waller, D.G., COX-2 Inhibitors and the cardiovascular system: Is there a class effect? 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year = "2006",
language = "English",
volume = "18",
pages = "219--230",
journal = "International Journal of Risk and Safety in Medicine",
issn = "0924-6479",
publisher = "IOS Press",
number = "4",
}