TY - JOUR
T1 - Fullerenes for the treatment of cancer
T2 - an emerging tool
AU - Fernandes, Neha Benedicta
AU - Shenoy, Raghavendra Udaya Kumar
AU - Kajampady, Mandira Kashi
AU - DCruz, Cleona E.M.
AU - Shirodkar, Rupesh K.
AU - Kumar, Lalit
AU - Verma, Ruchi
N1 - Funding Information:
Open access funding provided by Manipal Academy of Higher Education, Manipal This is a review article and does not having any financial support from any funding agency.
Funding Information:
The authors are thankful to the Manipal College of Pharmaceutical Sciences and Manipal Academy of Higher Education, Manipal, for providing online library access.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/8
Y1 - 2022/8
N2 - Cancer is a most common cause of mortality globally. Available medicines possess severe side effects owing to their non-specific targeting. Hence, there is a need of an alternative in the healthcare system that should have high efficacy with the least side effects, also having the ability to achieve site-specific targeting and be reproducible. This is possible with the help of fullerenes. Fullerenes are having the unique physicochemical and photosensitizer properties. This article discusses the synthesis, functionalization, mechanism, various properties, and applications of C60 fullerenes in the treatment of cancer. The review article also addresses the various factors influencing the activity of fullerenes including the environmental conditions, toxicity profile, and future prospective. Graphical abstract: [Figure not available: see fulltext.]
AB - Cancer is a most common cause of mortality globally. Available medicines possess severe side effects owing to their non-specific targeting. Hence, there is a need of an alternative in the healthcare system that should have high efficacy with the least side effects, also having the ability to achieve site-specific targeting and be reproducible. This is possible with the help of fullerenes. Fullerenes are having the unique physicochemical and photosensitizer properties. This article discusses the synthesis, functionalization, mechanism, various properties, and applications of C60 fullerenes in the treatment of cancer. The review article also addresses the various factors influencing the activity of fullerenes including the environmental conditions, toxicity profile, and future prospective. Graphical abstract: [Figure not available: see fulltext.]
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U2 - 10.1007/s11356-022-21449-7
DO - 10.1007/s11356-022-21449-7
M3 - Review article
C2 - 35790637
AN - SCOPUS:85133444804
SN - 0944-1344
VL - 29
SP - 58607
EP - 58627
JO - Environmental Science and Pollution Research
JF - Environmental Science and Pollution Research
IS - 39
ER -
