TY - JOUR
T1 - Genetic variants identified from GWAS for predisposition to type 2 diabetes predict sulfonylurea drug response
AU - Phani, N. M.
AU - Vohra, M.
AU - Adhikari, P.
AU - Nagri, S. K.
AU - Shashikiran, U.
AU - D’Souza, S. C.
AU - Kalluri, P. R.R.
AU - Satyamoorthy, K.
AU - Rai, P. S.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Background: Several SNPs were identified through GWAS for their association with type 2 diabetes which has implications to pancreatic β-cell physiology. Objective: We aimed to study the role of risk alleles of TCF7L2, KCNJ11, CDKN2A, CDKAL1, IGF2BP2, SLC30A8 and KCNQ1 along with pharmacokinetic variants in response to sulfonylureas. Method: We performed a prospective study on 209 newly diagnosed subjects; treatment naive T2D subjects were recruited. Individuals were started with glibenclamide monotherapy and followed-up for 12 weeks. Genotyping was done, using PCR-RFLP and TETRA-ARMS PCR and confirmed by DNA sequencing. Results: In univariate regression analysis, KCNJ11 (rs5219) was only the predictor for glibenclamide treatment failure. Conclusion: The present data suggests a possible role of KCNJ11 gene in altered response to glibenclamide.
AB - Background: Several SNPs were identified through GWAS for their association with type 2 diabetes which has implications to pancreatic β-cell physiology. Objective: We aimed to study the role of risk alleles of TCF7L2, KCNJ11, CDKN2A, CDKAL1, IGF2BP2, SLC30A8 and KCNQ1 along with pharmacokinetic variants in response to sulfonylureas. Method: We performed a prospective study on 209 newly diagnosed subjects; treatment naive T2D subjects were recruited. Individuals were started with glibenclamide monotherapy and followed-up for 12 weeks. Genotyping was done, using PCR-RFLP and TETRA-ARMS PCR and confirmed by DNA sequencing. Results: In univariate regression analysis, KCNJ11 (rs5219) was only the predictor for glibenclamide treatment failure. Conclusion: The present data suggests a possible role of KCNJ11 gene in altered response to glibenclamide.
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U2 - 10.2174/1566524018666180222122653
DO - 10.2174/1566524018666180222122653
M3 - Article
C2 - 29473503
AN - SCOPUS:85045896065
SN - 1566-5240
VL - 17
SP - 580
EP - 586
JO - Current Molecular Medicine
JF - Current Molecular Medicine
IS - 8
ER -
