TY - JOUR
T1 - Genome-wide analysis correlates Ayurveda Prakriti
AU - Govindaraj, Periyasamy
AU - Nizamuddin, Sheikh
AU - Sharath, Anugula
AU - Jyothi, Vuskamalla
AU - Rotti, Harish
AU - Raval, Ritu
AU - Nayak, Jayakrishna
AU - Bhat, Balakrishna K.
AU - Prasanna, B. V.
AU - Shintre, Pooja
AU - Sule, Mayura
AU - Joshi, Kalpana S.
AU - Dedge, Amrish P.
AU - Bharadwaj, Ramachandra
AU - Gangadharan, G. G.
AU - Nair, Sreekumaran
AU - Gopinath, Puthiya M.
AU - Patwardhan, Bhushan
AU - Kondaiah, Paturu
AU - Satyamoorthy, Kapaettu
AU - Valiathan, Marthanda Varma Sankaran
AU - Thangaraj, Kumarasamy
N1 - Funding Information:
This work was supported by the Office of the Principal Scientific Advisor to the Government of India; Department of Science and Technology (DST), Government of India (PRNSA/ADV/AYURVEDA/4/2007). KT was also supported by CSIR Network project - GENESIS (BSC0121), Government of India. We acknowledge the help of Dr. Ketaki Bapat for her constant support throughout the project tenure. We thank Dr. David Reich for his valuable suggestions.
PY - 2015/10/29
Y1 - 2015/10/29
N2 - The practice of Ayurveda, the traditional medicine of India, is based on the concept of three major constitutional types (Vata, Pitta and Kapha) defined as " Prakriti". To the best of our knowledge, no study has convincingly correlated genomic variations with the classification of Prakriti. In the present study, we performed genome-wide SNP (single nucleotide polymorphism) analysis (Affymetrix, 6.0) of 262 well-classified male individuals (after screening 3416 subjects) belonging to three Prakritis. We found 52 SNPs (p ≤ 1 ×10-5) were significantly different between Prakritis, without any confounding effect of stratification, after 10 6 permutations. Principal component analysis (PCA) of these SNPs classified 262 individuals into their respective groups (Vata, Pitta and Kapha) irrespective of their ancestry, which represent its power in categorization. We further validated our finding with 297 Indian population samples with known ancestry. Subsequently, we found that PGM1 correlates with phenotype of Pitta as described in the ancient text of Caraka Samhita, suggesting that the phenotypic classification of India € s traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine.
AB - The practice of Ayurveda, the traditional medicine of India, is based on the concept of three major constitutional types (Vata, Pitta and Kapha) defined as " Prakriti". To the best of our knowledge, no study has convincingly correlated genomic variations with the classification of Prakriti. In the present study, we performed genome-wide SNP (single nucleotide polymorphism) analysis (Affymetrix, 6.0) of 262 well-classified male individuals (after screening 3416 subjects) belonging to three Prakritis. We found 52 SNPs (p ≤ 1 ×10-5) were significantly different between Prakritis, without any confounding effect of stratification, after 10 6 permutations. Principal component analysis (PCA) of these SNPs classified 262 individuals into their respective groups (Vata, Pitta and Kapha) irrespective of their ancestry, which represent its power in categorization. We further validated our finding with 297 Indian population samples with known ancestry. Subsequently, we found that PGM1 correlates with phenotype of Pitta as described in the ancient text of Caraka Samhita, suggesting that the phenotypic classification of India € s traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine.
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U2 - 10.1038/srep15786
DO - 10.1038/srep15786
M3 - Article
C2 - 26511157
AN - SCOPUS:84946138433
SN - 2045-2322
VL - 5
JO - Scientific Reports
JF - Scientific Reports
M1 - 15786
ER -