Global protein sequence variation in HIV-1-b isolates derived from human blood and brain

Seetharaman Balaji; Patil Sneha; Murugappan Rama; Paul Shapshak

doi:10.1007/978-1-4939-2410-3_24

Global protein sequence variation in HIV-1-b isolates derived from human blood and brain

Seetharaman Balaji^*
, Patil Sneha
, Murugappan Rama
, Paul Shapshak

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

Abstract

The first part of this chapter introduces the proteins encoded by HIV-1. Their consensus sequences, structures, and functions are discussed. Amino acid sequence variations due to different selective pressures that drive the evolution of HIV-1 including compartmentalization and geographical variations are addressed. Sequence and phylogenetic analysis are used to identify conserved as well as variable regions of HIV-1-B isolates derived from human blood and brain. These signature sequences may have a significant impact on future vaccine design and development.

Original language	English
Title of host publication	Global Virology I-Identifying and Investigating Viral Diseases
Publisher	Springer New York
Pages	613-666
Number of pages	54
ISBN (Electronic)	9781493924103
ISBN (Print)	9781493924097
DOIs	https://doi.org/10.1007/978-1-4939-2410-3_24
Publication status	Published - 01-01-2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine
General Immunology and Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4939-2410-3_24

Cite this

@inbook{e4363bd51e1d459b9cf1d30cd96095c5,

title = "Global protein sequence variation in HIV-1-b isolates derived from human blood and brain",

abstract = "The first part of this chapter introduces the proteins encoded by HIV-1. Their consensus sequences, structures, and functions are discussed. Amino acid sequence variations due to different selective pressures that drive the evolution of HIV-1 including compartmentalization and geographical variations are addressed. Sequence and phylogenetic analysis are used to identify conserved as well as variable regions of HIV-1-B isolates derived from human blood and brain. These signature sequences may have a significant impact on future vaccine design and development.",

author = "Seetharaman Balaji and Patil Sneha and Murugappan Rama and Paul Shapshak",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2015.",

year = "2015",

month = jan,

day = "1",

doi = "10.1007/978-1-4939-2410-3\_24",

language = "English",

isbn = "9781493924097",

pages = "613--666",

booktitle = "Global Virology I-Identifying and Investigating Viral Diseases",

publisher = "Springer New York",

address = "United States",

}

TY - CHAP

T1 - Global protein sequence variation in HIV-1-b isolates derived from human blood and brain

AU - Balaji, Seetharaman

AU - Sneha, Patil

AU - Rama, Murugappan

AU - Shapshak, Paul

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The first part of this chapter introduces the proteins encoded by HIV-1. Their consensus sequences, structures, and functions are discussed. Amino acid sequence variations due to different selective pressures that drive the evolution of HIV-1 including compartmentalization and geographical variations are addressed. Sequence and phylogenetic analysis are used to identify conserved as well as variable regions of HIV-1-B isolates derived from human blood and brain. These signature sequences may have a significant impact on future vaccine design and development.

AB - The first part of this chapter introduces the proteins encoded by HIV-1. Their consensus sequences, structures, and functions are discussed. Amino acid sequence variations due to different selective pressures that drive the evolution of HIV-1 including compartmentalization and geographical variations are addressed. Sequence and phylogenetic analysis are used to identify conserved as well as variable regions of HIV-1-B isolates derived from human blood and brain. These signature sequences may have a significant impact on future vaccine design and development.

UR - https://www.scopus.com/pages/publications/84944555635

UR - https://www.scopus.com/pages/publications/84944555635#tab=citedBy

U2 - 10.1007/978-1-4939-2410-3_24

DO - 10.1007/978-1-4939-2410-3_24

M3 - Chapter

AN - SCOPUS:84944555635

SN - 9781493924097

SP - 613

EP - 666

BT - Global Virology I-Identifying and Investigating Viral Diseases

PB - Springer New York

ER -

Global protein sequence variation in HIV-1-b isolates derived from human blood and brain

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this