Global protein sequence variation in HIV-1-b isolates derived from human blood and brain

Seetharaman Balaji; Patil Sneha; Murugappan Rama; Paul Shapshak

doi:10.1007/978-1-4939-2410-3_24

Global protein sequence variation in HIV-1-b isolates derived from human blood and brain

Seetharaman Balaji^*
, Patil Sneha
, Murugappan Rama
, Paul Shapshak

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

Abstract

The first part of this chapter introduces the proteins encoded by HIV-1. Their consensus sequences, structures, and functions are discussed. Amino acid sequence variations due to different selective pressures that drive the evolution of HIV-1 including compartmentalization and geographical variations are addressed. Sequence and phylogenetic analysis are used to identify conserved as well as variable regions of HIV-1-B isolates derived from human blood and brain. These signature sequences may have a significant impact on future vaccine design and development.

Original language	English
Title of host publication	Global Virology I-Identifying and Investigating Viral Diseases
Publisher	Springer New York
Pages	613-666
Number of pages	54
ISBN (Electronic)	9781493924103
ISBN (Print)	9781493924097
DOIs	https://doi.org/10.1007/978-1-4939-2410-3_24
Publication status	Published - 01-01-2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine
General Immunology and Microbiology

Access to Document

10.1007/978-1-4939-2410-3_24

Cite this

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AU - Shapshak, Paul

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AB - The first part of this chapter introduces the proteins encoded by HIV-1. Their consensus sequences, structures, and functions are discussed. Amino acid sequence variations due to different selective pressures that drive the evolution of HIV-1 including compartmentalization and geographical variations are addressed. Sequence and phylogenetic analysis are used to identify conserved as well as variable regions of HIV-1-B isolates derived from human blood and brain. These signature sequences may have a significant impact on future vaccine design and development.

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PB - Springer New York

ER -

Global protein sequence variation in HIV-1-b isolates derived from human blood and brain

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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