TY - JOUR
T1 - Haematological indices in acute coronary syndromes
T2 - Could there be a hidden message?
AU - Biswas, Monalisa
AU - Belle, Vijetha Shenoy
AU - Vimal Krishnan, S.
AU - Prabhu, Krishnananda
N1 - Funding Information:
The authors sincerely thank the Dean of Kasturba Medical College, Manipal, and the management of Manipal Academy of Higher Education for providing us with the platform, infrastructure, and encouragement for research activities. We also thank the University Grants Commission and the Council for Scientific and Industrial Research for supporting the present study through fellowship and contingency support to our Ph.D. scholars.
Publisher Copyright:
© 2022, Indian Association of Biomedical Scientists. All rights reserved.
PY - 2022/12/31
Y1 - 2022/12/31
N2 - Introduction and Aim: The routine markers of CAD show elevation after the development of acute manifestations. There exists a need for the establishment/validation of biomarkers that predict preclinical atherosclerotic changes. This study assesses the utility of haematological indices in the prediction and prognostication of CAD. Materials and Methods: This retrospective study includes 830 patient reports investigated for serum Troponin T retrieved from the laboratory information system. Reports were grouped into positive and negative categories. Relevant haematological and biochemical data were retrieved. Statistical analysis was carried out to estimate group differences, correlation, sensitivity, specificity, and AUC. Results: Troponin T positive group showed significantly elevated WBCs, neutrophils, CRP, NLR, PLR, and SII with significantly low lymphocytes, monocytes, basophils and RBC count. None of the lipid profile parameters, except serum triglyceride, showed significant differences between groups. Males showed a higher baseline but a blunter elevation CRP during acute coronary events. ROC showed maximum sensitivity (75.9%) and NPV (77.9%) for NLR, while PLR showed maximum specificity (76.4%). Conclusion: Haematological indices may have a better predictive value than conventional lipid profile and might serve as key markers in novel cardiac risk screening panels and aid in the risk stratification and management of coronary artery diseases.
AB - Introduction and Aim: The routine markers of CAD show elevation after the development of acute manifestations. There exists a need for the establishment/validation of biomarkers that predict preclinical atherosclerotic changes. This study assesses the utility of haematological indices in the prediction and prognostication of CAD. Materials and Methods: This retrospective study includes 830 patient reports investigated for serum Troponin T retrieved from the laboratory information system. Reports were grouped into positive and negative categories. Relevant haematological and biochemical data were retrieved. Statistical analysis was carried out to estimate group differences, correlation, sensitivity, specificity, and AUC. Results: Troponin T positive group showed significantly elevated WBCs, neutrophils, CRP, NLR, PLR, and SII with significantly low lymphocytes, monocytes, basophils and RBC count. None of the lipid profile parameters, except serum triglyceride, showed significant differences between groups. Males showed a higher baseline but a blunter elevation CRP during acute coronary events. ROC showed maximum sensitivity (75.9%) and NPV (77.9%) for NLR, while PLR showed maximum specificity (76.4%). Conclusion: Haematological indices may have a better predictive value than conventional lipid profile and might serve as key markers in novel cardiac risk screening panels and aid in the risk stratification and management of coronary artery diseases.
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U2 - 10.51248/.v42i6.2065
DO - 10.51248/.v42i6.2065
M3 - Article
AN - SCOPUS:85146227843
SN - 0970-2067
VL - 42
SP - 1178
EP - 1184
JO - Biomedicine
JF - Biomedicine
IS - 6
ER -