TY - JOUR
T1 - Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection
T2 - To treat or not to treat
AU - Fazal, Farhan
AU - Gupta, Nitin
AU - Ramu, Shivabalan Kathavarayan
AU - Nayan, Aditya
AU - Vikram, Naval Kishore
AU - Ray, Animesh
N1 - Publisher Copyright:
© Farhan Fazal et al.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Haemophagocytic lymphohistiocytosis (HLH) in Human Immunodeficiency Virus (HIV) infected individuals can either be due to the disease itself or due to associated infections/malignancies. The treatment for HLH requires immunosuppressive therapy but administering immunosuppressive therapy to an already immunosuppressed patient (HIV infection) is complex. We present two such cases of HLH in patients infected with HIV. In the first case, no alternate cause for HLH was found even after extensive investigations and it was attributed to the uncontrolled HIV replication. Patient was started on dexamethasone for the same but succumbed to hospital acquired pneumonia. The second patient was diagnosed with Hodgkin's lymphoma but he succumbed to his illness before initiating immunosuppressive therapy for HLH. We report these cases to highlight the dilemma and a need for further research in this direction
AB - Haemophagocytic lymphohistiocytosis (HLH) in Human Immunodeficiency Virus (HIV) infected individuals can either be due to the disease itself or due to associated infections/malignancies. The treatment for HLH requires immunosuppressive therapy but administering immunosuppressive therapy to an already immunosuppressed patient (HIV infection) is complex. We present two such cases of HLH in patients infected with HIV. In the first case, no alternate cause for HLH was found even after extensive investigations and it was attributed to the uncontrolled HIV replication. Patient was started on dexamethasone for the same but succumbed to hospital acquired pneumonia. The second patient was diagnosed with Hodgkin's lymphoma but he succumbed to his illness before initiating immunosuppressive therapy for HLH. We report these cases to highlight the dilemma and a need for further research in this direction
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U2 - 10.11604/pamj.2019.32.105.14764
DO - 10.11604/pamj.2019.32.105.14764
M3 - Article
C2 - 31223395
AN - SCOPUS:85067119711
SN - 1937-8688
VL - 32
JO - Pan African Medical Journal
JF - Pan African Medical Journal
M1 - 105
ER -
