HDL or hs-CRP: The Prognostic Conundrum in Acute Coronary Syndrome

There is a dearth of information from research regarding the correlation between high density lipoprotein (HDL) and high-sensitivity C-reactive protein (hs-CRP) and acute coronary syndrome (ACS). The objective of our research was to look into their relationship as well as their impact on the hospital mortality and clinical outcomes of ACS patients. Patient of either gender of age > 18 years with new onset of ACS confirmed by clinical presentation, ECG changes and levels of cardiac necrosis biomarkers were included in the study. Complete blood count, HDL, hs-CRP and albumin investigations were done. Based on their HDL cholesterol levels, patients were categorized into three groups: very low HDL, low HDL, and normal HDL. The results demonstrated a strong and statistically significant correlation between hs-CRP and HDL (p < 0.05). No relationship was observed between low HDL and total counts in patients with ACS. Correlation of inflammatory markers with HDL level showed that hs-CRP is highly corelated with HDL (r = − 0.419, p < 0.001), whereas albumin and WBC was not statistically significant. Although low HDL does not directly correlate with the severity of the disease, low HDL-c is a risk factor for coronary heart disease. Elevated hs-CRP levels in ACS patients are linked to heart failure, severe left ventricular dysfunction, and a higher risk of hospital complications. As a result, hs-CRP can be regarded as a relatively simple biomarker that aids in determining the patient’s spectrum with ACS.