@article{0ec33d51066f40d0bca6f688ce56fae2,
title = "Healing potential of Anogeissus latifolia for dermal wounds in rats",
abstract = "Wound healing potential of ethanolic extract of Anogeissus latifolia bark (ALE) for treatment of dermal wounds in rats was studied on excision and incision wound models. HPTLC of the total extract was recorded for the purpose of standardization. Various parameters of incision wound, viz. epithelization period, scar area, tensile strength and hydroxyproline measurements along with wound contraction, were used to evaluate the effect of A. latifolia on wound healing. The results obtained indicate that A. latifolia accelerates the wound healing process by decreasing the surface area of the wound and increasing the tensile strength. Nitrofurazone ointment was used as a positive control. Complete epithelization was observed within 15 days with ALE. Measurements of the healed area and the hydroxyproline level were in agreement. Antibacterial activity of ALE was studied against Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) compared to erythromycin and tetracycline. Moderate activity was observed against all organisms. The present study provides a scientific rationale for the traditional use of Anogeissus latifolia in the management of skin diseases such as sores, boils and itching.",
author = "R. Govindarajan and M. Vijayakumar and C.V. Rao and A. Shirwaikar and S. Mehrotra and P. Pushpangadan",
note = "Cited By :40 Export Date: 10 November 2017 CODEN: ACPHE Correspondence Address: Govindarajan, R.; Pharmacog. and Ethnopharmacol. Div., Natl. Botanical Research Institute, Lucknow-226 001, India; email: govind108@yahoo.com Chemicals/CAS: erythromycin, 114-07-8, 70536-18-4; hydroxyproline, 51-35-4, 6912-67-0; nitrofural, 59-87-0; tetracycline, 23843-90-5, 60-54-8, 64-75-5; Anti-Bacterial Agents; Ointments; Plant Extracts References: Chattopadhyay, D., Arunachalam, G., Mandai, A.B., Sur, T.K., Mandal, S.C., Bhattacharya, S.K., Antimicrobial and anti-inflammatory activity of folklore: Mellotus peltatus leaf extract (2002) J. Ethnopharmacol., 82, pp. 229-237; Phillips, G.D., Whitehe, R.A., Kinghton, R., Initiation and pattern of angiogenesis in wound healing in the rat (1991) Amer. J. Anat., 192, pp. 257-262; Sidhu, G.S., Mani, H., Gaddipatti, J.P., Singh, A.K., Seth, P., Banaudha, K.K., Patnaik, G.K., Maheshwari, R.K., Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice (1999) Wound Repair Regen., 7, pp. 362-374; Udupa, A.I., Kulkarni, D.R., Udupa, S.L., Effect of Tridax procumbens extracts on wound healing (1995) Int. J. Pharmacol., 33, pp. 37-40; Porras-Reyes, H., Lewis, W.H., Roman, J., Simchowitz, L., Mustoe, T.A., Enhancement of wound healing by the alkaloid taspine defining mechanism of action (1993) Soc. Exp. Biol. Med., 203, pp. 18-25; Suh, D., Schwartz, I.P., Canning, D.A., Snyder, H.M., Zderic, S.A., Kirsch, A.J., Comparison of dermal and epithelial approaches to laser tissue soldering for skin flap closure (1998) Lasers Sur. Med., 22, pp. 268-274; Thiem, B., Grosslinka, O., Antimicrobial activity of Rubus chamaemorus leaves (2003) Fitoterapia, 75, pp. 93-95; Reddy, K.K., Rajadurai, S., Nayudamma, Y., Studies on Dhava (Anogeissus latifolia) tannins: Part III - Polyphenols of bark, sapwood and heartwood of Dhava (1965) Indian J. Chem., 3, pp. 308-310; Deshpande, V.H., Patil, A.D., Rama Rao, A.V., Venkatraman, K., Chemical constituents of Anogeissus latifolia heartwood: Isolation of 3,3′-di-O-methylellagic acid-4′-β-D-glucoside (1976) Indian J. Chem., 14 B, pp. 641-643; Roy, G.P., Chaturvedi, G.P., Ethnomedicinal trees of Abujh-Marh area, Madhya Pradesh (1986) Folklore, 27, pp. 95-100; Jain, S.K., Tarafder, C.R., Medicinal plant lore of the Santal. A revival of P. O. Budding's work (1970) Econ. Bot., 24, pp. 241-278; Apparanantham, T., Chelladurai, V., Glimpses on folk medicines of Dharmapuri forest division, Tamilnadu (1986) Anc. Sci. Life, 5, pp. 182-185; Balla, N.P., Sahu, T.R., Mishra, G.P., Traditional plant medicines of Sagar Distt. Madhyapradesh (1982) J. Econ. Tax. Bot., 3, pp. 23-32; Ramachandran, V.S., Nair, N.C., Ethnobotanical studies in Cannanore district, Kerala state (1981) J. Econ. Tax. Bot., 2, pp. 183-190; Govindarajan, R., Vijayakumar, M., Rao, Ch.V., Shirwaikar, A., Rawat, A.K.S., Mehrotra, S., Pushpangadan, P., Estimation of the antioxidant potential of Anogeissus latifolia (2004) Biol. Pharm. Bull., 27, pp. 1266-1269; Sen, C.K., Khanna, S., Gordillo, G., Bagchi, D., Bagchi, M., Roy, S., Oxygen, oxidants, and antioxidants in wound healing: An emerging paradigm (2002) Ann. NY Acad. Sci., 957, pp. 239-249; (1996) Indian Pharmacopoeia, 2nd Ed., , Goverment of India, New Delhi; (1985) Guide for the Care and Use of Laboratory Animals, 2nd Ed., , DHEW publication, Bethesda; Chatterjee, T.K., Chakravorty, A., Wound healing properties of the new antibiotics (MT81) in mice (1993) Indian Drugs, 30, pp. 450-452; Werner, S., Breeden, M., Hubner, G., Greenhalgh, D.G., Longaker, M.T., Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse (1994) J. Invest. Dermatol., 103, pp. 469-473; Neuman, R.E., Logan, M.A., The determination of hydroxyproline (1950) J. Biol. Chem., 184, pp. 299-306; Martin, A., The use of antioxidants in healing (1996) Dermatol. Surg., 22, pp. 156-160",
year = "2004",
language = "English",
volume = "54",
pages = "331--338",
journal = "Acta Pharmaceutica",
issn = "1330-0075",
publisher = "Croatian Pharmaceutical Society",
number = "4",
}