TY - JOUR
T1 - Hemoglobin, Vitamin D, and lipids in subclinical hypothyroid patients - Do the anti -thyroid autoantibodies titer matters?
AU - Jaseem, T.
AU - Hegde, Anupama
AU - Chakrapani, M.
AU - Rao, Sathish
N1 - Publisher Copyright:
© 2017 Oriental Scientific Publishing Company. All rights reserved.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Hashimoto's thyroiditis, the commonest cause of hypothyroidism has been proposed as a risk factor for atherosclerosis independent of thyroid function. The aim of this study was to investigate whether Hashimoto's thyroiditis validated by their anti-TPO positivity have any effect on hyperlipidemia, Hemoglobin, Vitamin D independent of thyroid function in newly diagnosed subclinical hypothyroid patients (SCH) subjects with TSH ≤ 10μIU/ml. 40 newly diagnosed SCH and 40 healthy euthyroid controls were included in this study. Based on anti-TPO status, the SCH subjects was divided into TPO positive and negative groups. Serum lipid, hemoglobin and Vitamin D levels were determined and compared between among the TPO positive and negative SCH subjects. Subjects with and without anti-TPO had significant differences in levels of low-density lipoprotein, total cholesterol, and nonHDL cholesterol. In correlation analysis, anti-TPO showed statistically significant association with Hb, LDL and Vitamin D. Subclinical hypothyroidism with thyroid autoimmunity is associated with a marginal decrease in hemoglobin and elevation in LDL. Whether this holds, any bearing on promoting cardiovascular risk needs to be considered further.
AB - Hashimoto's thyroiditis, the commonest cause of hypothyroidism has been proposed as a risk factor for atherosclerosis independent of thyroid function. The aim of this study was to investigate whether Hashimoto's thyroiditis validated by their anti-TPO positivity have any effect on hyperlipidemia, Hemoglobin, Vitamin D independent of thyroid function in newly diagnosed subclinical hypothyroid patients (SCH) subjects with TSH ≤ 10μIU/ml. 40 newly diagnosed SCH and 40 healthy euthyroid controls were included in this study. Based on anti-TPO status, the SCH subjects was divided into TPO positive and negative groups. Serum lipid, hemoglobin and Vitamin D levels were determined and compared between among the TPO positive and negative SCH subjects. Subjects with and without anti-TPO had significant differences in levels of low-density lipoprotein, total cholesterol, and nonHDL cholesterol. In correlation analysis, anti-TPO showed statistically significant association with Hb, LDL and Vitamin D. Subclinical hypothyroidism with thyroid autoimmunity is associated with a marginal decrease in hemoglobin and elevation in LDL. Whether this holds, any bearing on promoting cardiovascular risk needs to be considered further.
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U2 - 10.13005/bpj/1218
DO - 10.13005/bpj/1218
M3 - Article
AN - SCOPUS:85044861940
SN - 0974-6242
VL - 10
SP - 1175
EP - 1180
JO - Biomedical and Pharmacology Journal
JF - Biomedical and Pharmacology Journal
IS - 3
ER -