Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 79-88 |
| Number of pages | 10 |
| Journal | Acta Pharmaceutica Turcica |
| Volume | 47 |
| Issue number | 1 |
| Publication status | Published - 2005 |
| Externally published | Yes |
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In: Acta Pharmaceutica Turcica, Vol. 47, No. 1, 2005, p. 79-88.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Hepatoprotective activity of Nelumbo nucifera Geartn. Flower: An ethnopharmacological study
AU - Rao, G.M.M.
AU - Pushpangadan, P.
AU - Shirwaikar, A.
N1 - Cited By :9 Export Date: 10 November 2017 CODEN: APTUE Correspondence Address: Rao, G.M.M.; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow-226 001, Uttarpradesh, India; email: mmraos@rediffmail.com Chemicals/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; alcohol, 64-17-5; alkaline phosphatase, 9001-78-9; aspartate aminotransferase, 9000-97-9; bilirubin, 18422-02-1, 635-65-4; carbon tetrachloride, 56-23-5; paracetamol, 103-90-2; silymarin, 65666-07-1 Manufacturers: Sigma, United States; suzen, India References: Ahmed, M.B., Khater, M.R., Evaluation of the protective potential of Ambrosia maritima extract on acetaminophen-induced liver damage (2001) J. Ethnopharmacol., 75, pp. 169-174; (1986) Useful Plants of India, p. 394. , CSIR, New Delhi; Ansari, R.A., Tripathi, S.C., Patnaik, G.K., Dhawan, B.N., Anti-hepatotoxic properties of picroliv, an active fraction from rhizomes of Picrorhiza kurroa (1991) J. Ethnopharmacol., 34, pp. 61-68; Brent, J.A., Ruack, B.H., Role of free radicals in toxic hepatic injury II (1993) Clin. Toxicol., 31, pp. 173-196; Chao, J.M., Marderosian, A.H., Identification of ergoline alkaloids in the genus Argyreia and related genera and there chemo taxonomic implications in the Convolvulaceae (1973) Phytochem., 12, pp. 2435-2440; Dhuley, G.P., Naik, S.R., Protective effect of Rhinax, a herbal formulation against CCl4 induced liver injury and survival in rats (1997) J. Ethnopharmacol., 56, pp. 159-164; Drotman, R.B., Lawhorn, G.T., Serum enzymes as indicators of chemical-induced liver damage (1978) Drug. Chem. Toxicol., 1, pp. 163-171; Eriksson, L., Broome, U., Kahn, M., Lindholm, M., Hepatotoxicity due to repeated intake of low doses of paracetamol (1992) J. Int. Med., 231, pp. 567-570; Grover, J.K., Yadav, S., Vats, V., Medicinal plants of India with anti-diabetic potential (2002) J. Ethnopharmacol., 81 (1), pp. 81-100; Joshi, R., Garg, B.D., Analysis of the fatty acid composition of Argyeria speciosa (1981) J. Sci. Res., 3, pp. 195-198; Jung, H.A., Kim, J.E., Chung, H.Y., Chois, J.S., Antioxidant principles of Nelumbo nucifera stamens (2003) Arch. Pharm. Res., 26 (4), pp. 279-285; King, E.J., Armsrong, A.R., Calcium, magnesium, phosphorus and phosphatase (1980) Pract. Clin. Biochem., 1, p. 850. , Varley, B., Gowenlock, A.H., Bell, M. (Eds.). Heinemann, London; Kuma, S., Rex, D., Failure of physicians to recognise acetaminophen hepatotoxicity in chronic alcoholics (1991) Arch. Int. Med., 151, pp. 1189-1191; La, C.B., Molgaard, P., Yi, Z., Traditional Chinese medicine in treatment of hyperlipidaemia (1995) J. Ethnopharmacol., 46 (2), pp. 125-129; Latha, U., Rajesh, M.G., Latha, M.S., Hepatoprotective effect of an ayurvedic medicine (1999) Ind. Drugs, 36, pp. 470-473; Lee, S.E., Hwang, H.J., Ha, J.S., Jeong, H.S., Kim, J.H., Screening of medicinal plant extracts for antioxidant activity (2003) Life Sci., 73, pp. 167-179; Malloy, J.R., Jollow, Evelyn, K.A., The determination of bilirubin with the photometric colorimeter (1937) J. Biol. Chem., 119, pp. 481-490; Mazumder, U.K., Gupta, M., Pramanik, G., Mukhopadhyay, R.K., Sarkar, S., Antifertility activity of seed of Nelumbo nucifera in mice (1992) Indian J. Exp. Biol., 30 (6), pp. 533-534; Mitchell, J.R., Jollow, D.J., Potter, W.Z., Gillette, J.R., Brodie, B.N., Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism (1973) J. Pharmacol. Exp. Therapeutic., 187, pp. 185-194; Mitra, S.K., Seshadri, S.J., Venkataranganna, M.V., Gopumadhavan, S., Venkatesh Udupa, U., Sarma, D.N.K., Effect of HD-03- a herbal formulation in galactosamine-induced hepatopathy in rats (2000) Indian J. Physiol. Pharmacol., 44, pp. 82-86; Rao, G.M.M., Rao, C.H.V., Sudhakar, M., Pandey, M.M., Rawat, A.K.S., Shirwaikar, A., Joshi, A.B., Anti-inflammatory and Antinociceptive activities of Coccinia indica Fruit juice powder in animals (2004) Nat. Prod. Sci., 10, pp. 20-23; Rao, G.M.M., Vijayakumar, M., Rao, Ch.V., Rawat, A.K.S., Mehrotra, S., Hepatoprotective effect of Coccinia indica against carbon tetrachloride induced hepatotoxicity (2003) Nat. Prod. Sci., 9, pp. 13-17; Mukherjee, P.K., Saha, K., Pal, M., Saha, B.P., Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats (1997) J. Ethnopharmacol., 58, pp. 207-213; Mukherjee, P.K., Saha, K., Das, J., Pal, M., Saha, B.P., Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera (1997) Planta Med., 63, pp. 367-369; Nazirogulu, M., Cay, M., Ustundag, B., Aksakal, M., Yekeller, H., Protective effects of vitamin E on carbon tetrachloride-induced liver damage in rats (1999) Cell Biochem. Function, 17, pp. 253-259; Reitman, S., Frankel, S., A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases (1957) American J. Clin. Path., 28, pp. 53-56; Schmidt, E., Schmidt, F.W., (1967) Guide to Practical Enzyme Diagnosis, p. 15. , Boehringer Manaheion Gmbh, West Germany; Schmidt, E., Schmidt, F.W., Mohr, J., Otto, P., Vido, I., Wrogeman, K., Herfarth, C., Liver Morphology and enzyme release. Further studies in the isolated perfused rat liver (1975) Pathogenesis and Mechanism of Liver Cell Necrosis, p. 147. , Keppler (Ed.). Medical and Technical publishing Co. Ltd., Lancaster; Singh, A., Handa, S.S., Hepatoprotective activity o Apium graveolens and Hygrophilla auriculata against paracetamol and thioacetamide intoxication in rats (1995) J. Ethnopharmacol., 49, pp. 119-126; Sohn, D.H., Kim, Y.C., Oh, S.H., Park, E.J., Li, X., Lee, H.B., Hepatoprotective and free radical scavenging effects of Nelumbo nucifera (2003) Phytomedicine, 10, pp. 165-167; Srivastava, A., Shukla, Y.N., Aryl esters and a coumarin from Argyeria speciosa (1998) Indian J. Chem., 37 (B), pp. 192-194; Thabrew, M.I., Joice, P.D.T.M., Rajatissa, W., A comparative study of the efficacy of Pavetta indica and Osbekia octandra in the treatment of liver dysfunction (1987) Planta Med., 53, pp. 239-241; Venkateswaran, S., Pari, L., Viswanathan, P., Menon, V.P., Protective effect of a herbal formulation against erythromycin estolate-induced hepatotoxicity in rats (1997) J. Ethnopharmacol., 57, pp. 161-167; Vermuelen, N.P.E., Bessems, J.G.M., Van De Streat, R., Molecular aspects of paracetamol induced hepatotoxicity and its mechanism based prevention (1992) Drug Metab. Rev., 24, pp. 367-407; Visen, P.K.S., Shukla, B., Patnaik, G.K., Dhawan, B.N., Andrographolide protects rat hepatocytes against paracetamol-induced damage (1993) J. Ethnopharmacol., 40, pp. 131-136; Wells, F.E., Tets in liver and biliary tract disease (1988) Varley's Practical Clinical Biochemistry, , Gowenlock, H.A. (Ed.). CRC Press, Florida; Wilkinson, J.H., (1962) An Introduction to Diagnostic Enzymology, p. 84. , Edward Arnold, London; Woolson, R.F., (1987) Statistical Methods for the Analysis of Biomedical Data, , John Wiley and Sons Inc., New York; Wu, M.J., Wang, L., Weng, C.Y., Yen, J.H., Antioxidant activity of methanol extract of the lotus leaf (Nelumbo nucifera Gertn.) (2003) Am. J. Chin. Med., 31, pp. 687-698; Zimmerman, H.J., Seef, L.B., Enzymes in hepatic disease (1970) Diagnostic Enzymology, , Goodly, E.I. (Ed,), Lea and Febiger, Philadelphia; Zimmerman, M., Ethical guidelines for investigation of experimental pain in conscious animal (1983) Pain, 16, pp. 109-110
PY - 2005
Y1 - 2005
N2 - Nelumbo nucifera Geartn. (Nymphaeaceae), a medicinal plant mentioned in Ayurveda for the treatment of liver disorders, has not been subjected to systematic scientific investigations to assess its hepatoprotective effects. The present study was therefore, undertaken to investigate the hepatoprotective activity of this plant. 50% aqueous ethanolic extract of flowers of Nelumbo nucifera Geartn. (Nymphaeaceae) showed a significant dose dependent (200 mg, 400 mg/kg p.o. × 10) protective effect against carbon tetrachloride and paracetamol induced hepatotoxicity in Sprague-Dawley rats. The degree of protection was measured using biochemical parameters like serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum alkaline phosphatase (SAKP) and serum bilirubin (SB). Liver sections were also studied histopathologically to confirm the biochemical results. The results indicated that the 400 mg/kg p.o. of 50% aqueous ethanolic extract of flowers of Nelumbo nucifera Geartn. exhibited the most significant (P
AB - Nelumbo nucifera Geartn. (Nymphaeaceae), a medicinal plant mentioned in Ayurveda for the treatment of liver disorders, has not been subjected to systematic scientific investigations to assess its hepatoprotective effects. The present study was therefore, undertaken to investigate the hepatoprotective activity of this plant. 50% aqueous ethanolic extract of flowers of Nelumbo nucifera Geartn. (Nymphaeaceae) showed a significant dose dependent (200 mg, 400 mg/kg p.o. × 10) protective effect against carbon tetrachloride and paracetamol induced hepatotoxicity in Sprague-Dawley rats. The degree of protection was measured using biochemical parameters like serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum alkaline phosphatase (SAKP) and serum bilirubin (SB). Liver sections were also studied histopathologically to confirm the biochemical results. The results indicated that the 400 mg/kg p.o. of 50% aqueous ethanolic extract of flowers of Nelumbo nucifera Geartn. exhibited the most significant (P
M3 - Article
SN - 1307-2080
VL - 47
SP - 79
EP - 88
JO - Acta Pharmaceutica Sciencia
JF - Acta Pharmaceutica Sciencia
IS - 1
ER -