@article{ebd7e5ec3b8948148ac4abe9b51ccac4,
title = "Hepatoprotective activity of Polygala elongata against CCl 4-induced hepatotoxicity in rats",
abstract = "The ethanolic extract of the plant Polygala elongata Klein Ex.Willd (Polygalaceae) was investigated for its hepatoprotective activity in male Wistar rats. In acute toxicity studies, the extract when administered to mice as a single i.p. dose of 1000 mg/kg was found to be non toxic. The extract exhibited significant hepatoprotective activity at 200 mg/kg body weight, which was comparable to the activity exhibited by the reference standard, Silymarin in carbon tetrachloride-induced hepatoxicity model. Mangiferin, a xanthone, was the main component isolated from the ethyl methyl ketone fraction of the ethanolic extract. The flavonold, quercetin-3-O-β-D glucoside was also isolated from the ethyl acetate fraction.",
author = "A. Shirwaikar and R. Padma and {Vasanth Kumar}, A. and L. Rao",
note = "Cited By :2 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal-576 119, India; email: annie.shirwaikar@cops.manipal.edu References: Chopra, R.N., Nayar, S.L., Chopra, I.C., (1956) Glossary of Indian Medicinal Plants, p. 21. , CSIR, Publication and Information Directorate, New Delhi; Maclean, A.E.M., (1975) Models of Liver Diseases, Karger, Tiffenia, p. 2. , Italy; Reitman, S., Frankel, S., (1975) Amer. J. Clin. Pathol, 28, p. 56; Kerman, A., (1955) J. Clin. Invest, 33, p. 131; Armilage, P., Berry, G., (1985) Statistical Methods in Medical Research, p. 186. , 2nd Edn, Blackwell Scientific Publications, Oxford; (1980) Remington's Pharmaceutical Sciences, p. 119. , Osol, A, Eds, 16th Edn, Mack Publishing Company, Pennsylvania; Recknagel, R.P. and Glende, E.A., CRC Critical Rev. Toxicology, 1973, 3, 263; Slater, T.F., (1966) Nature (London), 209, p. 36; Sherlock, S., (1981) Biochemical Assessment of Liver Function, p. 14. , Blackwell Scientific Publications, Oxford; Ghosal, S., Rao, G., (1996) Indian J. Chem, 35, p. 561; Soicke, H., Leng-Peschlow, E., (1987) Planta Med, 53, p. 37; Bezonger, L.B., Trupin, N., Guilbert, N., Guislin, R., (1964) C. R. Soc. Biol, 158, p. 2095",
year = "2002",
language = "English",
volume = "64",
pages = "345--348",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "4",
}