@article{11ba7cae2a434d5899eb126615056117,
title = "Hepatoprotective properties of Caesalpinia sappan Linn. heartwood on carbon tetrachloride induced toxicity",
abstract = "Aim of the study was to investigate the methanol and aqueous extracts of heartwood of C. sappan for its hepatoprotective activity against CCl4 induced toxicity in freshly isolated rat hepatocytes and animals. Freshly isolated rat hepatocytes were exposed to CCl4 (1%) along with/without various concentrations of methanolic and aqueous extract of C. sappan (1000-800 μg/ml) and the levels of selected liver enzymes were estimated. Antihepatotoxic effect of methanolic extract was observed in freshly isolated rat hepatocytes at concentrations 1000-800 μg/ml and was found to be similar to that of standard drug silymarin. Wistar strain albino rat model was used for the investigation of in vivo hepatoprotective properties of aqueous and methanolic extract of C. sappan (100 and 200 mg/kg body weight). Liver damage was induced by ip administration of CCl4 (30%) suspended in olive oil (1 ml/kg body weight). Both the tested extracts showed potent hepatoprotective activity at 200 mg/kg body weight test dose which was comparable with that of the standard silymarin used in similar test dose. The methanolic and aqueous extract was able to restore the biochemical levels to normal which were altered due to CCl4 intoxication in freshly isolated rat hepatocytes and also in animals.",
author = "V.S. Srillakshmi and P. Vijayan and P.V. Raj and S.A. Dhanaraj and H.R. Chandrashekhar",
note = "Cited By :19 Export Date: 10 November 2017 CODEN: IJEBA Correspondence Address: Chandrashekhar, H. R.; Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104, India; email: raghushekhar@gmail.com Chemicals/CAS: carbon tetrachloride, 56-23-5; Carbon Tetrachloride, 56-23-5; Plant Extracts; Protective Agents References: Kirtikar, K.R., Basu, B.D., (1987) Indian Medicinal Plants, p. 847. , International Book Distributors, Dehradun India; Warrier, P.K., Nambiar, V.P.K., Ramankutty, C., Vaidyarathnam P S Varrier's Indian Medicinal Plants (1993) A Compendium of 500 Species, 1, p. 291. , Orient Longman Ltd., Chennai, India; Baek, N.I., Jeon, S.G., Ahn, E.M., Hahn, J.H., Jang, J.S., Cho, S.W., Park, J.K., Choi, S.Y., Anticonvulsant compounds from the wood of Caesalpinia sappan L (2000) Arch Pharm Res, 23, p. 344; Hikino, H., Taguchi, T., Fujimura, H., Hiramatsu, Y., Anti-inflammatory principles of Caesalpinia sappan wood and of Haematoxylon campechianum wood (1977) Planta Med, 31, p. 214; Ueda, J.Y., Tezuka, Y., Banskota, A.H., Tran, L.Q., Tran, Q.K., Harimaya, Y., Saiki, I., Kadota, S., Anti-proliferative activity of Vietnamese medicinal plants (2002) Biol Pharm Bull, 25, p. 753; Yadava, R.N., In vitro antimicrobial studies on the saponin obtained from Caesalpinia sappan Linn (1989) Asian J Chem, 1, p. 88; Kurokawa, M., Ochlal, H., Naga, S.K., Neki, M., Xu, H.X., Antiviral traditional medicines against herpes simples virus (HSV-1) (1993) Antiviral Res, 22, p. 175. , poliovirus and measles virus in vitro and their therapeutic efficacies for HSV-1 infection in mice; Kataoka, M., Takagaki, Y., Effect of the crude drugs on {\ss}-hexosaminidase release from rat basophilic leukemia (RBL-2H3) cells (1995) Nat Med, 49, p. 346; Moon, C.K., Sim, K.S., Lee, S.H., Park, S.H., Yun, Y.P., Antitumor activity of some phyto based polysaccharides and their effects on the immune function (1983) A Srch Pharm Res, 6, p. 123; Xie, Y.W., Ming, D.S., Xu, H.X., Dong, H., But, P.P., Vasorelaxing effects of Caesalpinia sappan involvement of endogenous nitric oxide (2000) Life Sci, 67, p. 1913; Badami, S., Moorkoth, S., Rai, S.R., Elango, K., Suresh, B., Antioxidant activity of Caesalpinia sappan heartwood (2003) Biol Pharm Bull, 26, p. 1534; Moon, C.K., Park, K.S., Kim, S.G., Won, H.S., Chung, J.H., Brazilin protects cultured rat hepatocytes from BrCCl3 induced toxicity (1992) Drug Chem Toxicol, 15, p. 81; Seglen, P.O., Culture of specific cell types: Epithelial cells - Isolation of hepatocytes (1994) Cell Biology: A Laboratory Handbook, 1, p. 96. , edited by Julio E. 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year = "2010",
language = "English",
volume = "48",
pages = "905--910",
journal = "Indian Journal of Experimental Biology",
issn = "0019-5189",
publisher = "National Institute of Science Communication",
number = "9",
}