TY - JOUR
T1 - Hesperidin inhibits nitrite-induced methemoglobin formation
AU - Sudheer Kumar, M.
AU - Srinivasan, K.K.
AU - Unnikrishnan, M.K.
N1 - Cited By :1
Export Date: 10 November 2017
CODEN: IJSID
Correspondence Address: Unnikrishnan, M. K.; Department of Pharmacology, College of Pharmaceutical Sciences, Manipal-576 119, India; email: [email protected]
References: Chen, Y.T., Zheng, R.L., Jia, Z.J., Ju, Y., (1990) Free Radical Biol. Med, 9, p. 19; Ratty, A.K., Das, N.P., (1988) Biochem. Med. Metab. Biol, 39, p. 69; Doyle, M.P., Pickering, R.A., Dykstra, R.L., Nelson, C.L., Boyer, R.F., (1982) Biochem. Biophy. Res. Commun, 105, p. 127; Wallace, W.J., Houtchens, R.A., Maxwell, J.C., Caughey, W., (1982) J. Biol. Chem, 257, p. 4966; Tomoda, A., Tsuiji, A., Yoneyama, Y., (1981) Biochem. J, 193, p. 169; Unnikrishnan, M.K., Rao, M.N.A., (1992) FEBS Lett, 301, p. 195; Smith, R.C., Nunn, V., (1984) Arch. Biochem. Biophys, 232, p. 348
PY - 2003
Y1 - 2003
N2 - Hesperidin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection was not observed when hesperidin was added after the autocatalytic stage of the oxidation of hemoglobin. The ability of hesperidin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.
AB - Hesperidin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection was not observed when hesperidin was added after the autocatalytic stage of the oxidation of hemoglobin. The ability of hesperidin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.
M3 - Article
SN - 0250-474X
VL - 65
SP - 436
EP - 438
JO - Indian Journal of Pharmaceutical Sciences
JF - Indian Journal of Pharmaceutical Sciences
IS - 4
ER -