High-sensitive C-reactive protein levels in diabetes associated with dyslipidemia

Background: There is compelling evidence that inflammation is an important risk factor in cardiovascular disease (CVD) and diabetes mellitus. High-sensitive C-reactive protein (hs-CRP) is a predictive marker of inflammation as well as metabolic syndrome. Aims and Objectives: The purpose of this study was to correlate the significance of hs-CRP with cholesterol, triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein (LDL) in patients with long-term hyperglycemia and healthy control group. Materials and Methods: This study involved 311 subjects (150 patients, 161 control group; between 40 and 65 years of age, mean age of patients and control group were 51.4 ± 9.6, 45.96 ± 3, respectively). Serum concentration of aforementioned analytes was measured among the patients and controls. Results: The concentration of parameters among case and control group were total cholesterol (227.84 ± 28.3, 167.45 ± 21.63 mg/dl), LDL cholesterol (158.43 ± 25.65, 117.30 ± 31.27 mg/dl), HDL-C (27.67 ± 11.11, 51.74 ± 12.61 mg/dl), TG (211.34 ± 36.42, 98.13 ± 67.40 mg/dl), and hs-CRP (29.49 ± 5.90, 2.18 ± 1.10 mg/L) were measured by Cobas 6000 autoanalyzer. A statistically significant (P < 0.001) difference was found in both groups. Conclusion: Diabetes mellitus has a profound effect on lipid metabolism and patient’s lipid profile need to be monitored and managed frequently to prevent further complication such as CVD that may arise as a result of dyslipidemia.