Histoplasmosis, heart failure, hemolysis and haemophagocytic lymphohistiocytosis

Nitin Gupta; Kutty Sharada Vinod; Ankit Mittal; Aswin Pius Ajay Kumar; Arvind Kumar; Naveet Wig

doi:10.11604/pamj.2019.32.43.14954

Histoplasmosis, heart failure, hemolysis and haemophagocytic lymphohistiocytosis

Nitin Gupta, Kutty Sharada Vinod, Ankit Mittal, Aswin Pius Ajay Kumar, Arvind Kumar, Naveet Wig^*

^*Corresponding author for this work

Department of Infectious Diseases, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Histoplasmosis is an endemic mycosis with global distribution, primarily reported in immunocompromised individuals. A 29-year old immunocompetent male presented with fever, hepatosplenomegaly and pancytopenia. His peripheral blood showed features suggestive of intravascular hemolysis and echocardiography showed features suggestive of pulmonary arterial hypertension. Bone marrow showed yeast with morphology suggestive of Histoplasma capsulatum. Further investigations revealed hyperferritinemia, hypofibrinogenemia and increased triglycerides. With a diagnosis of progressive disseminated histoplasmosis with secondary Haemophagocytic lymphohistiocytosis, he was successfully treated with amphotericin B followed by itraconazole. We report this case to highlight the atypical and rare manifestations of histoplasmosis.

Original language	English
Article number	43
Journal	Pan African Medical Journal
Volume	32
DOIs	https://doi.org/10.11604/pamj.2019.32.43.14954
Publication status	Published - 01-01-2019

All Science Journal Classification (ASJC) codes

General Medicine

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10.11604/pamj.2019.32.43.14954

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abstract = "Histoplasmosis is an endemic mycosis with global distribution, primarily reported in immunocompromised individuals. A 29-year old immunocompetent male presented with fever, hepatosplenomegaly and pancytopenia. His peripheral blood showed features suggestive of intravascular hemolysis and echocardiography showed features suggestive of pulmonary arterial hypertension. Bone marrow showed yeast with morphology suggestive of Histoplasma capsulatum. Further investigations revealed hyperferritinemia, hypofibrinogenemia and increased triglycerides. With a diagnosis of progressive disseminated histoplasmosis with secondary Haemophagocytic lymphohistiocytosis, he was successfully treated with amphotericin B followed by itraconazole. We report this case to highlight the atypical and rare manifestations of histoplasmosis.",

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AU - Vinod, Kutty Sharada

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AU - Kumar, Arvind

AU - Wig, Naveet

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AB - Histoplasmosis is an endemic mycosis with global distribution, primarily reported in immunocompromised individuals. A 29-year old immunocompetent male presented with fever, hepatosplenomegaly and pancytopenia. His peripheral blood showed features suggestive of intravascular hemolysis and echocardiography showed features suggestive of pulmonary arterial hypertension. Bone marrow showed yeast with morphology suggestive of Histoplasma capsulatum. Further investigations revealed hyperferritinemia, hypofibrinogenemia and increased triglycerides. With a diagnosis of progressive disseminated histoplasmosis with secondary Haemophagocytic lymphohistiocytosis, he was successfully treated with amphotericin B followed by itraconazole. We report this case to highlight the atypical and rare manifestations of histoplasmosis.

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Histoplasmosis, heart failure, hemolysis and haemophagocytic lymphohistiocytosis

Abstract

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