TY - JOUR
T1 - Hot-melt extrusion technique
T2 - A novel continuous manufacturing method for enteric-coated pellets
AU - Roychowdhury, Rajeshwari
AU - Kara, Divya Dhatri
AU - Rathnanand, Mahalaxmi
N1 - Funding Information:
The authors would like to thank the Manipal College of Pharmaceutical Sciences, MAHE, Manipal, India. The authors are also thankful for Biorender.com, an image-making tool.
Publisher Copyright:
© 2021. Rajeshwari Roychowdhury et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
PY - 2021/7
Y1 - 2021/7
N2 - The technology of hot-melt extrusion (HME) is becoming a progressively appealing way to develop different drug delivery systems. A wide range of pharmaceutical dosage forms and formulations from oral to topical and parenteral can be prepared. The dosage forms formulated using HME technique are composite mixtures of active pharmaceutical agents, active excipients, and other processing aids. HME has many advantages over traditional techniques of pharmaceutical development, such as non-solvent technology, lower processing requirements, uninterrupted activity, and greater possibility of uniform suspension and increased bioavailability. This paper addresses enteric-coated pellet pharmaceutical applications and its process techniques using the HME technology and its applications in pharmaceutical industries for an efficient pathway for a novel drug delivery system.
AB - The technology of hot-melt extrusion (HME) is becoming a progressively appealing way to develop different drug delivery systems. A wide range of pharmaceutical dosage forms and formulations from oral to topical and parenteral can be prepared. The dosage forms formulated using HME technique are composite mixtures of active pharmaceutical agents, active excipients, and other processing aids. HME has many advantages over traditional techniques of pharmaceutical development, such as non-solvent technology, lower processing requirements, uninterrupted activity, and greater possibility of uniform suspension and increased bioavailability. This paper addresses enteric-coated pellet pharmaceutical applications and its process techniques using the HME technology and its applications in pharmaceutical industries for an efficient pathway for a novel drug delivery system.
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U2 - 10.7324/JAPS.2021.110702
DO - 10.7324/JAPS.2021.110702
M3 - Article
AN - SCOPUS:85110553008
SN - 2231-3354
VL - 11
SP - 13
EP - 19
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 7
ER -
