HPTLC method for the estimation of fexofenadine HCL in tablet dosage form

P. Solairaj; A. R. Bhat; Suvarna G. Kini; R. Govindarajan; R. Venkatraman

HPTLC method for the estimation of fexofenadine HCL in tablet dosage form

P. Solairaj, A. R. Bhat, Suvarna G. Kini, R. Govindarajan, R. Venkatraman

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The paper describes HPTLC method for the estimation of fexofenadine HCl from tablet dosage form that employs a precoated silica gel G60 F₂₅₄ on aliminium sheet and a mobile phase comprising of dichloromethane; methanol (65;35%v/v) and subsequently scanned and quantified at 260 nm, the linear detector response was observed between 0.2 μg to 1.0 μg. The method so developed was validated to determine its accuracy and precision. The limit of detection and limit of quantitation was found to be 0.08ng/μl & 0.2 g/μl. The recovery was carried out by standard addition method and was found to be 100.82%.

Original language	English
Pages (from-to)	424-427
Number of pages	4
Journal	Indian Drugs
Volume	42
Issue number	7
Publication status	Published - 01-07-2005

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science
Drug Discovery

Cite this

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abstract = "The paper describes HPTLC method for the estimation of fexofenadine HCl from tablet dosage form that employs a precoated silica gel G60 F254 on aliminium sheet and a mobile phase comprising of dichloromethane; methanol (65;35%v/v) and subsequently scanned and quantified at 260 nm, the linear detector response was observed between 0.2 μg to 1.0 μg. The method so developed was validated to determine its accuracy and precision. The limit of detection and limit of quantitation was found to be 0.08ng/μl & 0.2 g/μl. The recovery was carried out by standard addition method and was found to be 100.82%.",

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AU - Solairaj, P.

AU - Bhat, A. R.

AU - Kini, Suvarna G.

AU - Govindarajan, R.

AU - Venkatraman, R.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - The paper describes HPTLC method for the estimation of fexofenadine HCl from tablet dosage form that employs a precoated silica gel G60 F254 on aliminium sheet and a mobile phase comprising of dichloromethane; methanol (65;35%v/v) and subsequently scanned and quantified at 260 nm, the linear detector response was observed between 0.2 μg to 1.0 μg. The method so developed was validated to determine its accuracy and precision. The limit of detection and limit of quantitation was found to be 0.08ng/μl & 0.2 g/μl. The recovery was carried out by standard addition method and was found to be 100.82%.

AB - The paper describes HPTLC method for the estimation of fexofenadine HCl from tablet dosage form that employs a precoated silica gel G60 F254 on aliminium sheet and a mobile phase comprising of dichloromethane; methanol (65;35%v/v) and subsequently scanned and quantified at 260 nm, the linear detector response was observed between 0.2 μg to 1.0 μg. The method so developed was validated to determine its accuracy and precision. The limit of detection and limit of quantitation was found to be 0.08ng/μl & 0.2 g/μl. The recovery was carried out by standard addition method and was found to be 100.82%.

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AN - SCOPUS:77954714242

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JO - Indian Drugs

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IS - 7

ER -

HPTLC method for the estimation of fexofenadine HCL in tablet dosage form

Abstract

All Science Journal Classification (ASJC) codes

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